Aktivitas Antimitotik Dari Ekstrak Karang Lunak Genus Sinularia

Abstract

Soft coral genus Sinularia be a sources of terpenoid compounds that show efficacy in vitro cytotoxic test using cancer cell lines. The study looked at the morphological changes that occur in fungal mycelial growth of Pyricularia oryzae, such as curling effect indicating antimitotic activity. Four extracts of soft coral genus Sinularia have been examination and this is an primary test to obtain information about the soft coral genus Sinularia that used as sources of compound antimitotic. This research was conducted in several stages, ie extraction of bioactive substances, P. oryzae fungal culture test, and biological testing antimitotic activity with a qualitative assessment methods. From the examination the Sinularia 3 ethyl acetate fraction show the strongest antimitotic activity (to concentration 1,5 µg/ml). Ethyl acetate fraction was purified using column chromatography. From the examination show that fraction of ethyl acetate 1 is the best fraction because still show curling effect on concentration 0,7 µg/ml.

Identifikasi Metabolit Sekunder dan Aktivitas Antioksidan Karang Lunak Nephthea sp. Hasil Transplantasi Secara In Situ dan Ex Situ

“…Salah satu peran ekosistem terumbu karang adalah marine natural product (MNP) yang berasal dari metabolit sekunder organisme laut. Organisme laut penyusun ekosistem terumbu karang yang memiliki metabolit sekunder di antaranya adalah karang lunak (Patra & Majumdar, 2004;Tanod et al, 2015;Kawung et al, 2017;Kowal et al, 2018), alga (Tanod et al, 2015), spons (Luissandy et al, 2017;, dan Ascidian (Sumilat et al, 2017;. Karang lunak Nephthea sp.…”

“…merupakan organisme laut penyusun ekosistem terumbu karang. Organisme laut penyusun ekosistem terumbu karang merupakan penghasil senyawa bioaktif atau metabolit sekunder yang potensial (Tanod et al, 2015).…”

Antibacterial Potential of Soft Coral Lobophytum sp. From Pangalisang Waters of Bunaken Island to Pseudomonas aeruginosa and Staphylococcus aure

“…Dimana keanekaragaman tersebut berpotensi sebagai penghasil senyawa bioaktif yang baru. Organisme laut seperti karang lunak (Kawung et al, 2017), spons (Luissandy et al, 2017;Sumilat, 2017a), ascidian (Sumilat et al, 2017b;Sumilat et al, 2018), makro alga, mikro alga dan ikan merupakan penghasil senyawa bioaktif yang potensial dari produk alam laut (Tanod, 2015) Biota sesil terumbu karang seperti karang lunak merupakan sumber penghasil senyawa bioaktif yang potensial. Secara ekologis, biota yang tidak mampu berpindah tempat ini memproduksi senyawa bioaktif sebagai alternatif dalam berinteraksi atau berkompetisi di lingkungannya.…”

Antibacterial Activity and Molecular Identification of Soft Coral Sinularia sp. Symbiont Bacteria from Karimunjawa Island against Skin Pathogens Propionibacterium acnes and Staphylococcus epidermidis

“…One of the biotas that inhabit coral reefs is soft coral. Tanod et al [8] stated that soft corals (phylum Cnidaria) are invertebrate animals that live in coral reef ecosystems. Soft corals (Octocorallia, Alcyonacea) are included in the Coelenterata animals that live in tropical and subtropical shallow waters [9].…”