Background: One of the important things in menstruation is about the menstrual cycle. The menstrual cycle in every woman is not always regular. Changes in the menstrual cycle are quite common problems with a 75% prevalence in adolescents. In addition, in a study in adolescents that is about 65% of those who experience menstrual cycle changes. Objectives: Knowledge of factors that is associated with the menstrual cycle. Method: This research used descriptive analytic research type. The approach used in this research was cross sectional research design. Samples were 99 with random sampling technique. The bivariate analysis method used was chi square and multivariate analysis with logistic regression. Results: The factors shown to be associated with menstrual cycle changes were nutritional status, activity pattern, and psychological status. The result of bivariate analysis showed that nutritional status of p value (0,007 < 0,05), activity pattern p value (0,000 < 0,05), psychological status p (0,025 < 0,05). The result of multivariate analysis showed that the activity pattern had the closest relationship among other factors. This was evidenced by the value Exp (B) p: 0,000; OR: 8,096 which meant student with abnormal activity pattern at risk 8 times has irregular menstrual cycle. Conclusion and Suggestion: There is correlation between nutritional status, activity pattern, and psychological status with menstrual cycle change. This research expects to increase knowledge insight to female.