Aktuelle Übersicht zum Dermisersatz mit Kollagen-Elastin-Matrix Matriderm® bei Brandverletzungen

Kolokythas, P.; Aust, Matthias; Vogt, Peter M.; Paulsen, Friedrich

doi:10.1055/s-2008-1038459

Cited by 43 publications

(12 citation statements)

References 10 publications

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“…With the progression of healing process, fibroblasts lay down the ECM and the Matriderm ® resorbs [109]. Permacol has a good aesthetic and functional outcome but is prone to infection, hematomas, and seromas [73,74], whereas, Matriderm involves a single stage procedure with increased vascularization and elasticity of regenerating tissue but lacks enough scientific evidence to verify its efficacy of a one-step procedure [103,110,111]. Another substitute is Oasis, which is derived from porcine intestinal submucosa [79,85].…”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

534

418

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Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

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Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

534

418

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“…[27] In experimental models, the matrix reduces wound contracture, and histologically collagen bundles in the scar are more randomly orientated. Clinical trials with a long-term clinical evaluation showed no difference in scar elasticity between the described dermal substitute and split thickness grafts alone.…”

Section: Classificationsmentioning

confidence: 99%

Biologic and synthetic skin substitutes: An overview

Halim

Khoo

Yussof

2010

Indian J Plast Surg

314

169

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The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesised on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialisation characteristics due to the presence of a basement membrane. Synthetic skin substitutes demonstrate the advantages of increase control over scaffold composition. The ultimate goal is to achieve an ideal skin substitute that provides an effective and scar-free wound healing.

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“…Current indications for Matriderm are extensive cutanenous defects, like second- to third-degree burn wounds, large decollements or the revision of large, adherent scars [4,5,6]. Our case demonstrates that it is also possible to use a combination of Matriderm with autologous split-skin grafts to cover deep wounds with exposed tendons resulting in an excellent functional and cosmetic outcome.…”

Section: Discussionmentioning

confidence: 80%