Akutes Leberversagen nach Pilzingestion

Abstract

This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. After quantitative determination of the Amanita toxins the patients were immediately transferred to a university hospital.Poisoning by the death cap mushroom is responsible for acute hepatic and often also renal failure and is accompanied by a high mortality. Clinical symptoms follow a three-phase course with gastrointestinal complaints, an asymptomatic interval and finally the hepatorenal phase. Even in suspected cases of intoxication, treatment should be started by antidote therapy with silibinin.

Poisoning with Amanita phalloides (Vaill. ex Fr.) Link - 25-years retrospective analysis in Varna region, Bulgaria

“…In Bulgaria, Silibinin, (3,22,31,32), or 30% in adults and 50% in children (4,8). A. phalloides mushrooms frequently cause acute liver failure, and sometimes acute renal failure and are associated with high lethality (2,33,34).…”