Severe Mushroom Poisoning in One Macedonian Family

Chibishev, Andon; Perevska, Zanina; Simonovska, Natasha; Petkovska, Lidija; Miletic, Milena; Shikole, Emilija

doi:10.5301/ijao.5000428

Cited by 7 publications

(7 citation statements)

References 29 publications

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“…Thus, the first stage is defined by a latent period (6–40 hours) with no apparent symptoms, whereas the second stage is characterized by gastrointestinal symptoms, such as abdominal pain, nausea, vomiting, or loose stools. [17] In the third stage, the patient experiences an apparent improvement of clinical symptoms contrasting with the severe deterioration of laboratory parameters. [17] The last stage of this intoxication is characterized by the association between acute liver failure, hepatic encephalopathy, hyperbilirubinemia, impairment of coagulation status, acute renal failure, and hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…[17] In the third stage, the patient experiences an apparent improvement of clinical symptoms contrasting with the severe deterioration of laboratory parameters. [17] The last stage of this intoxication is characterized by the association between acute liver failure, hepatic encephalopathy, hyperbilirubinemia, impairment of coagulation status, acute renal failure, and hypoglycemia. [17] Both our cases expressed this pattern of mushroom intoxication.…”

Section: Discussionmentioning

confidence: 99%

“…[17] The last stage of this intoxication is characterized by the association between acute liver failure, hepatic encephalopathy, hyperbilirubinemia, impairment of coagulation status, acute renal failure, and hypoglycemia. [17] Both our cases expressed this pattern of mushroom intoxication. The impairment of coagulations test may result in different types of hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Most often, this hepatotoxin is an amatoxin resulting in severe hepatic cytolysis, being responsible in 90% of the cases for the fatal outcome of these patients. [17] Thus, every year up to 100 fatalities due to mushroom poisoning are reported worldwide, and most of them are caused by acute liver failure. [18]…”

Section: Introductionmentioning

confidence: 99%

“…Multiple therapeutic approaches have been used in severe cases of wild mushroom poisoning, such as plasmapheresis; the molecular adsorbent recirculating system (MARS) and different antidotes reported as useful, such as silibin, penicillin G, N-acetylcysteine, or high doses of ascorbic acid. [17] Despite all these therapeutic attempts, the occurrence of acute liver and renal failure leads eventually to a fatal outcome in these patients, most-likely due to Amanita poisoning.…”

Section: Introductionmentioning

confidence: 99%

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Mushroom intoxication, a fatal condition in Romanian children

Mărginean¹,

Meliţ²,

Mărginean

2019

Medicine

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Rationale:Approximately 5000 species of wild mushroom are reported worldwide, of which 100 are documented as poisonous and <10 are fatal. The clinical picture of patients with wild mushroom intoxication depends mostly on the type of ingested mushroom, ranging from mild gastrointestinal symptoms to organ failure and death.Patient concerns:We report 2 children, sister and brother admitted in our clinic for gastrointestinal symptoms: abdominal pain, nausea, vomiting, and diarrhea after wild mushroom ingestion.Diagnosis:The laboratory tests revealed hepatic cytolysis syndrome, hyperbilirubinemia, impaired coagulation status, hypoalbuminemia, hypoglycemia, and electrolytic unbalances in both cases. Abdominal ultrasound showed hepatomegaly and ascites.Intervention:After admission, both cases received penicillin by vein, activated charcoal, liver protectors, glucose, and electrolytes perfusions. Nevertheless, their status worsened and required the transfer to the pediatric intensive care unit for appropriate supportive measure. Therefore, therapeutic plasma exchange was initiated along with N-acetyl cysteine and hemostatic drugs.Outcomes:Despite all these therapeutic interventions, both cases developed hepatorenal syndrome and died after a couple of days from ingestion.Lessons:Mushroom poisoning remains a public health problem in developing countries. Preventable strategies and education regarding the consumption of wild type mushrooms are essential for decreasing the morbidity and mortality rates in these areas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mushroom intoxication, a fatal condition in Romanian children

Mărginean¹,

Meliţ²,

Mărginean

2019

Medicine

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Epidemiological analysis of wild mushroom poisoning in Zhejiang province, China, 2016–2018

Chen

Sun

Liao

et al. 2021

Food Science & Nutrition

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Wild mushroom poisoning has been recognized as a global problem threatening human health. In this study, we aimed to explore characteristics of wild mushroom poisoning in Zhejiang province, China. From 2016 to 2018, 429 cases of wild mushroom poisoning were reported, and among them, there were 2 deaths and 84 hospitalizations, with the incidence of 0.2526 per 100,000 and the case fatality rate of 0.47%. Digestive symptoms were found in all cases. Systemic symptoms and signs, neurological symptoms, and urinary symptoms were found in 28.90% (124/429), 11.66% (50/429), and 4.90% (21/429) of the cases, respectively. The proportion of cases with incubation period <6 h was 85.78%, and those with ≥6 h accounted for 14.22%. The peak period of poisoning occurred from June to October annually. Quzhou (Moran’s I = 1.242, p < .05) and Lishui (Moran’s I = 0.759, p < .05) with mild climate, more mountains, and abundant rainfall were “hot spots” for the incidence of wild mushroom poisoning, showing a state of high‐incidence aggregation. Epidemiological analysis showed that there were seasonal, high‐incidence areas and high‐risk groups in wild mushroom poisoning. The government should give early warning to high‐incidence areas and strengthen publicity to high‐risk groups before wild mushrooms mature every summer and autumn. In addition, we recommend that ordinary people not pick wild mushrooms outdoors for consumption, because it is difficult to distinguish whether wild mushrooms are poisonous and do not buy wild mushrooms of unknown sources.

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