Alaninaminopeptidase (Aminosäure-arylamidase) im Harn bei De Toni-Debré-Fanconi-Syndrom

Peters, Jǒrg E; Schneider, Ingeborg; Unger, G; Fukala, E; Gerlach, W.; Böhme, I; Haltrich, Edgar; Haschen, Reinhard J.

doi:10.1016/0009-8981(70)90031-8

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1972

1992

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“…Isoelectric points and antigenic properties are identical, but the molecular weights differ by a factor of about 2. Therefore, the greater electrophoretic mobility is due to the smaller size of the atypical enzyme.with Fanconi syndrome caused by cystinosis [7]. Similar to the enzyme from blood plas ma, it had a greater electrophoretic mobility in agar gel than the normal tubular enzyme.…”

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confidence: 94%

A Low Molecular Weight Alanine Aminopeptidase in Urine

Neef¹,

Hj²,

Böhme³

et al. 1982

Enzyme

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Using agarose gel electrophoresis, a faster moving alanine aminopeptidase (EC 3.4.11.2) has been demonstrated in the urine from cases of Fanconi syndrome, endemic (Balkan) nephropathy and advanced renal insufficiency. The enzyme was partially purified and its properties (isoelectric point, molecular weight, substrate specificity, influence of metal ions, Michaelis constant, antigenic behavior) were compared with those of normal kidney alanine aminopeptidase. Isoelectric points and antigenic properties are identical, but the molecular weights differ by a factor of about 2. Therefore, the greater electrophoretic mobility is due to the smaller size of the atypical enzyme.

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confidence: 94%