Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release

Abstract

The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble compounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to improve their apparent solubilities under physiologically relevant conditions with surfactants as wetting agents. Albendazole (ABZ), one of the most effective broad-spectrum antihelminthic agents, has a very low aqueous solubility, which leads to an erratic availability. Solid dispersions (SD) with different amounts of carriers (P188 and PEG6000) were formulated to improve the ABZ dissolution rate. When the dissolution test is used to infer biopharmaceutical properties of the dosage form, it is essential that the method simulates the gastrointestinal conditions. The objective of this study was to examine the applicability of different dissolution media to the evaluation of ABZ and ABZ-SD dissolution rates. Dissolution profiles were performed by the official method (0.1 N HCl) and Simulated Gastric Fluid modified with a surfactant. Wetting was evaluated through the determination of surface tension and contact angle of the solutions. The dissolution rate of ABZ was clearly affected by the variables assessed in this study. These results have implications in the design of physiologically based dissolution media.

Characterization of nimesulide and development of immediate release tablets

“…The results of the wettability test were all close to 80° (Table 1) and, in accordance with literature, the values close to 90° predict a poor wettability 24 . Although the literature does not present studies applying wettability test with nimesulide, some works with other drugs were conducted, in which the results of the contact angles were correlated with water solubility 25,26,27 .…”