Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using melting solidification printing process (MESO-PP) for oral administration of poorly soluble drugs

Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

“…Moreover, the drug remained crystalline in the NCs, but the endothermic melting peak shifted to a lower temperature and decreased its intensity. This fact has been shown previously in similar formulations containing P188, where a partial thermally-induced amorphization occurred during the heating process in the DSC experiment, and P188 melts at the early stages of the experiment [ 14 , 39 , 40 ]. The NCs-loaded eutectogel also presented similar characteristics, a CUR melting peak at around 155 ​°C.…”

Development of 3D-printed subcutaneous implants using concentrated polymer/drug solutions

“…Recently, the use of additive manufacturing (also known as 3D printing), which is a set of manufacturing techniques based on the deposition of material layer by layer for the building of a 3D object, has been utilised to great effect for this purpose (Domsta and Seidlitz, 2021). Previously, 3D printing has been explored for the design and manufacture of many drug delivery systems including suppositories (Seoane-Viaño et al, 2021) and oral tablets (Awad et al, 2020;Lopez-Vidal et al, 2022;Melocchi et al, 2020;Pandey et al, 2020;Tian et al, 2018). However, it has shown particular promise in the development of implantable medical devices, such as wound dressings (Teoh et al, 2021), surgical meshes (Domínguez-Robles et al, 2020;Farmer et al, 2021Farmer et al, , 2020, cardiovascular grafts (Domínguez-Robles et al, 2022, 2021b,2021aKabirian et al, 2018;Martin et al, 2021;Melchiorri et al, 2016) and subcutaneous implants (Korelidou et al, 2022;Liaskoni et al, 2021;Ruiz-Cantu et al, 2022;Stewart et al, 2020a;Stewart et al, 2020b).…”

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

“…Because of this, many different strategies were proposed to address this limitation. This includes amorphization [ 28 , 29 ], formation of monocrystals [ 30 , 31 ], micronization [ 32 ] and solid dispersion formation [ 33 ], complexation with cyclodextrins [ 34 , 35 ], salts [ 36 , 37 ] and cocrystals [ 38 , 39 ] formation. Another way of improving solubility involves cosolvation techniques in which a particular amount of a solvent is added to the primary solvent [ 40 , 41 , 42 ] resulting in elevated solubility.…”