Albumin as a drug: its biological effects beyond volume expansion

Bihari, Shailesh; Bannard-Smith, Jonathan; Bellomo, Rinaldo

doi:10.1016/s1441-2772(23)00394-0

Cited by 15 publications

(6 citation statements)

References 83 publications

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“…During CPB, albumin can maintain plasma oncotic pressure to achieve renal arterial perfusion pressure. It can also regulate inflammatory responses and reduce platelet aggregation, thereby mitigating the risk of renal inflammation and thrombus formation, and protecting the kidneys from injury ( 38 , 39 ). More importantly, human serum albumin (HSA) is the most important antioxidant in human plasma.…”

Section: Discussionmentioning

confidence: 99%

Risk factor and correlation between postoperative serum myoglobin and acute kidney injury after pulmonary endarterectomy

Xu,

Zhen,

Zhang

et al. 2024

J Thorac Dis

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Background Acute kidney injury (AKI) is a common and life-threatening complication following pulmonary endarterectomy (PEA). Our study aimed to investigate the risk factors associated with AKI and evaluate the correlation between serum myoglobin (sMb) levels and postoperative AKI. Methods We conducted a retrospective study involving 134 patients who underwent PEA at China-Japan Friendship Hospital. AKI was defined and staged according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Results During the study period, the incidence of postoperative AKI was 57.5%, and the associated mortality rate was 6.0%. Severe AKI was found to be significantly associated with worse short-term outcomes (P<0.05). Logarithmically transformed postoperative day (POD) 0 sMb levels were significantly associated with AKI [odds ratio (OR) =5.174; 95% confidence interval (CI), 2.307–11.603; P<0.001] and severe AKI (OR =4.605; 95% CI, 1.510–14.048; P=0.007), also had independent predictive value [area under the curve (AUC) =0.776 in AKI and AUC =0.737 in severe AKI]. The optimal cut-off values were 370.544 ng/mL for AKI and 419.473 ng/mL for severe AKI. Furthermore, albumin concentration was found to play a protective role in the development of severe AKI (OR =0.838; 95% CI, 0.716–0.980; P=0.027) when higher than 40.350 g/L. Conclusions Our findings suggest that a high concentration of POD0 sMb may increase the risk of developing AKI following PEA surgery. Increasing albumin concentration could serve as an effective preventive measure against AKI.

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Section: Discussionmentioning

confidence: 99%

Risk factor and correlation between postoperative serum myoglobin and acute kidney injury after pulmonary endarterectomy

Xu,

Zhen,

Zhang

et al. 2024

J Thorac Dis

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“… 39 Serum albumin plays an important role in volume expansion, maintenance of vascular endothelial integrity, and anti-inflammation. 40 Reduced serum albumin levels are strongly associated with mortality in patients with cardiovascular disease, heart failure, and cirrhosis. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors for Infection and Death in Critically Ill Patients with Pulmonary Infection with Elizabethkingia Spp.

Feng,

Huang,

Fan

et al. 2024

IDR

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“…Low serum albumin is significantly associated with mortality and morbidity in critically ill patients and after IHCA [15,42,43]. Human serum albumin possesses protective effects through anti-inflammatory properties and reduction of ischaemia-reperfusion injury, both of which might be important to counterbalance the post-resuscitation inflammatory response [44][45][46][47]. Similar to lactate, serum albumin levels are affected by multiple conditions, including inflammation, malnutrition, and liver cirrhosis [48].…”

Section: Discussionmentioning

confidence: 99%

Lactate to Albumin Ratio for Predicting Clinical Outcomes after In-Hospital Cardiac Arrest

Haschemi

Muller

Haurand

et al. 2023

JCM

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In-hospital cardiac arrest (IHCA) is associated with high mortality and poor neurological outcomes. Our objective was to assess whether the lactate-to-albumin ratio (LAR) can predict the outcomes in patients after IHCA. We retrospectively screened 75,987 hospitalised patients at a university hospital between 2015 and 2019. The primary endpoint was survival at 30-days. Neurological outcomes were assessed at 30 days using the cerebral performance category scale. 244 patients with IHCA and return of spontaneous circulation (ROSC) were included in this study and divided into quartiles of LAR. Overall, there were no differences in key baseline characteristics or rates of pre-existing comorbidities among the LAR quartiles. Patients with higher LAR had poorer survival after IHCA compared to patients with lower LAR: Q1, 70.4% of the patients; Q2, 50.8% of the patients; Q3, 26.2% of the patients; Q4, 6.6% of the patients (p = 0.001). Across increasing quartiles, the probability of a favourable neurological outcome in patients with ROSC after IHCA decreased: Q1: 49.2% of the patients; Q2: 32.8% of the patients; Q3: 14.7% of the patients; Q4: 3.2% of the patients (p = 0.001). The AUCs for predicting 30-days survival using the LAR were higher as compared to using a single measurement of lactate or albumin. The prognostic performance of LAR was superior to that of a single measurement of lactate or albumin for predicting survival after IHCA.

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Albumin as a drug: its biological effects beyond volume expansion

Cited by 15 publications

References 83 publications

Risk factor and correlation between postoperative serum myoglobin and acute kidney injury after pulmonary endarterectomy

Risk factor and correlation between postoperative serum myoglobin and acute kidney injury after pulmonary endarterectomy

Clinical Characteristics and Risk Factors for Infection and Death in Critically Ill Patients with Pulmonary Infection with Elizabethkingia Spp.

Lactate to Albumin Ratio for Predicting Clinical Outcomes after In-Hospital Cardiac Arrest

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