Albumin-based near-infrared phototheranostics for frequency upconversion luminescence/photoacoustic dual-modal imaging-guided photothermal therapy

Abstract

We constructed facile “one-for-all” phototheranostics (NRh-BSA NPs) assembled from an organic molecular dye (NRh) and BSA for frequency upconversion luminescence/photoacoustic (FUCL/PA) dual-modal imaging-guided photothermal therapy (PTT).

Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

“…Among them, frequency upconversion luminescence (FUCL) has gained prominence in biosensing and imaging due to its superior properties of deep-tissue penetration, low autofluorescence, high photostability, and high signal-to-noise ratio. Furthermore, diverse FUCL-based systems have been extensively developed for detecting metal ions, tumor hypoxia, and cancer therapy 35 , 36 , 37 , 38 , 39 , 40 , 41 . Recently, our group reported the design of 658 nm light-activable upconversion luminescent NO nano-prodrugs that facilitated precise real-time NO monitoring and tumor treatment guided by FUCL imaging 42 .…”