Albumin clearance in the endotoxemic rat after administration of Nω-nitro-L-arginine methyl ester (L-name)

Aminoguanidine does not influence tissue extravasation of albumin in endotoxaemic rats

“…However, in chloralose anaesthetised rats, control MAP, and the pressor response to yet another non‐selective inhibitor, (N G ‐nitro‐L‐arginine), were not significantly different from those in conscious animals (23). In other experiments in endotoxaemic rats in the present model, we have indeed observed a marked increase in blood pressure in response to L‐NAME (24). Our conclusion is that in our setting there was no important interference with the response to NO from anaesthesia.…”

Effective inhibition of nitric oxide production by aminoguanidine does not reverse hypotension in endotoxaemic rats

“…The data, however, should be regarded with some caution as the drug might have influenced constitutive NOS isoforms as well. Notwithstanding, the action on such NOS cannot have been pronounced as we, in other experiments (32), observed a pronounced pressor response to the non‐selective NOS inhibitor N ω ‐nitro‐L‐arginine‐methyl‐ester (L‐NAME). On the other hand, AG in non‐septic animals slightly increases arterial pressure and is inert on NOx levels (25).…”