Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Abstract

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

“…For instance, albumin-stabilized carbon-encapsulated iron oxide nanoparticles (Fe@C-BSA) have been evaluated as a potential agent for magnetic nano hyperthermia. Among the tested concentrations of Fe@C-BSA (1, 2.5, and 5 mg/mL) for induction heating, the SAR value was determined to be the highest (437.64 W/g) at the lowest concentration (1 mg/mL) (33).…”

Dual-color core–shell silica nanosystems for advanced super-resolution biomedical imaging

“…In recent years, multiple nanoparticle-based tools have been developed for biomedical applications drug delivery, 1,2 antibacterial activity, 3,4 sensing, [5][6][7][8] cancer therapy, 9 imaging and tissue engineering. [10][11][12] Focusing on imaging, dye-loaded SiO 2 NPs [11][12][13] are among the most used nanomaterials due to their advantageous properties, such as biocompatibility, 14,15 tunable size, good morphology and dispersion, and easy surface chemistry modication which allow molecules to be chemically bonded to their surface.…”