Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer

Sasidharan, Sisini; Bahadur, D.; Srivastava, Rohit

doi:10.1039/c6ra11405a

Cited by 27 publications

(27 citation statements)

References 34 publications

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“…[5][6][7][8] Surface loading and orientation (or conformation) of surface ligands will alter signicantly the interaction these nanostructures with cells by changing the activity of these ligands, but is rarely considered for rationale design of these particles. [9][10][11] Currently, it is unclear whether protein-gold nanoparticle (AuNP) binding (capacity or conformation) at the nanoparticle surface are dependent on their radius of curvature. It has been suggested that, for spherical, citrate capped AuNPs, surface curvature alters the structure and binding capacity of adsorbed proteins onto their surface, although this issue remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Geometry-induced protein reorientation on the spikes of plasmonic gold nanostars

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Geometry-induced protein reorientation on the spikes of plasmonic gold nanostars

et al. 2020

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“…In such cases, the risk of radiation-induced damage makes it difficult to discern if cell death is caused by hyperthermia through the photothermal effect or by the laser itself. However, even though photothermal therapy works by killing a high percentage of malignant cells by itself, combined approaches including drug delivery and photodynamic therapy controlled by external stimuli provide added value to photothermal systems 36,110…”

Section: Biomedical Applications Of Albumin-aunpsmentioning

confidence: 99%

“…Another interesting system is that described by Sashidaran et al,110 where gold nanostars (AuNSs) were synthesized through a simple wet chemistry route and subsequently BSA-functionalized, yielding a stable monodispersed solution, with an average particle size of 120 nm. AuNS-BSA did not exhibit any inherent cytotoxic activity towards healthy (L929) and cancerous (KB) cells, but it showed significant photothermal ablation properties after laser exposure, thereby working as a therapeutic agent.…”

Section: Biomedical Applications Of Albumin-aunpsmentioning

confidence: 99%

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

Bolaños

Kogan

Araya

2019

IJN

159

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Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.

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“…hemolysis Assay: The in-vitro hemolytic property of ALg-Propolis NPs was studied by quantifying the free hemoglobin (Hb) released into plasma after lysis of red blood cells (RBC) upon interaction with nanoparticles (Sasidharan et al, 2016). Fresh blood was taken from the jugular vein of cattle into heparin containing tubes as an anticoagulant.…”

Section: Preparation Of Alginate-propolis Npsmentioning

confidence: 99%

A New Approach to the Treatment of Lumpy Skin Disease Infection in Cattle by using Propolis Encapsulated within ALG NPS

Farag¹,

El-Houssiny²,

Abdel-Rahman³

et al. 2020

AAVS

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L umpy skin disease (LSD) is a contagious, fatal skin disease affecting cattle and caused by LSDV which belongs to the family Poxviridae. LSDV is a double-stranded DNA virus (Onyejekwe et al., 2019). It is a member of the genus Capripoxvirus of Poxviridae with the size of its genome 151-kbp (Bhanuprakash et al., 2006). LSDV is a transboundary high-impact cattle disease characterized by fever, nodular formation, a rapid eruption of skin nodules, enlarged superficial lymph node, generalized lymphadenitis, and edema with great economic losses (Abera et al., 2015, Şevik et al., 2016; Rouby et al., 2019). It is usually more prevalent during the wet summer and au-research Article Abstract | Background: Lumpy skin disease (LSD) is a contagious disease caused by the Lumpy skin disease virus (LSDV) which belongs to the genus Capripoxvirus of the family Poxviridae. Cattle are the only animal species affected, with high morbidity and mortality rate in the young. LSD causes economic losses, abortions in females, and sterility in males. Nanoparticles are one of the novel strategies that adopted in the treatment of diseases in the last few years owing to their pioneering and functional properties. Aim: This study aimed to treat the clinically infected cattle with LSDV using Propolis-Alginate nanoparticles (Propolis-ALg NPs) through different routes such as eye drop, oral route and topical spray. Materials and methods: The Propolis-ALg NPs were characterized through Transmission Electron Microscope (TEM), Differential Scanning Calorimetry (DSC), in-vitro cytotoxicity, and hemolysis assays. The animal study was carried out during the outbreak of LSD in July 2018 at Beni-suef Governorate, Egypt. 35 infected cows with different ages were used in the present study. The animals were divided into two groups; group A (20 animals) and group B(15 animals). Animals in group A were treated with Propolis-ALg NPs and animals in group B were treated with tetracycline antibiotics. Confirmation of the isolated LSDV was done by polymerase chain reaction (PCR) using universal primers. results: The Propolis-ALg NPs showed spherical morphology with small particle sizes. The thermal analysis revealed the successful encapsulation of the propolis within the ALg NPs. Also, the in-vitro cytotoxicity study confirmed the safety of the Propolis-ALg NPs. In addition to that, the prepared nanoparticles were found to be non-toxic when they come in contact with blood. On the other hand, the clinically infected cattle with LSDV which treated with the Propolis-ALg NPs revealed a 100 % recovery. While, the animals treated with the tetracycline showed only 13.3% recovery. conclusion: Therefore, the Propolis-ALg NPs were shown to be a potential candidate in the therapy against LSDV infections.

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Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer

Abstract: Albumin stabilization of gold nanostars, which demonstrate high stability, biocompatibility, superior CT contrast, SERS and photothermal cytotoxicity towards cancer cells.

Cited by 27 publications

References 34 publications

Geometry-induced protein reorientation on the spikes of plasmonic gold nanostars

Geometry-induced protein reorientation on the spikes of plasmonic gold nanostars

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

A New Approach to the Treatment of Lumpy Skin Disease Infection in Cattle by using Propolis Encapsulated within ALG NPS

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