Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator for patients undergoing minimally invasive lung cancer surgery: Propensity score matching analysis using a prospective database

Li, Shuangjiang; Lv, Wenyu; Du, Heng; Li, Yong-Jiang; Zhang, Wenbiao; Che, Guowei; Liu, Lunxu

doi:10.1016/j.ijsu.2019.07.008

Cited by 43 publications

(66 citation statements)

References 35 publications

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“…Respiratory comorbidity was defined as the presence of one or more respiratory diseases, including chronic obstructive pulmonary disease, emphysema, lung bullae, asthma, tuberculosis, pneumonia, bronchiectasis, lung abscess and interstitial lung diseases. Cardio‐cerebrovascular comorbidity included hypertension, coronary heart diseases, peripheral arterial diseases, stroke, aortic aneurysm and chronic heart failure …”

Section: Methodsmentioning

confidence: 99%

“…OS was defined as the survival time from the operation day to the date of death from any cause or to the time of censoring at the last follow‐up date. DFS was defined as the survival time from the operation day to the detection of cancer recurrence or metastasis …”

Section: Methodsmentioning

confidence: 99%

“…In the PSM model, the confounders must not be influenced by elements of SIRI, indicating that the laboratory biomarkers comprising of neutrophils, lymphocytes and monocytes (i.e. NLR, LMR and PLR) were not considered for PS balance . The 1:1 matched pairs were finally created according to their PS.…”

Section: Methodsmentioning

confidence: 99%

“…The most routine appointments, including physical examination, laboratory testing, chest computed tomography (CT), upper-abdominal CT and brain magnetic resonance imaging or CT, were provided in compliance with our institutional policies. 12 A regular telephone follow-up would be prepared if patients could not come to outpatient clinic. This follow-up assessment was performed every 3 months for the first 2 years and every 6 months for the next 3 years.…”

Section: Follow-up Investigationmentioning

confidence: 99%

“…Cardio-cerebrovascular comorbidity included hypertension, coronary heart diseases, peripheral arterial diseases, stroke, aortic aneurysm and chronic heart failure. 1,3,12 Laboratory markers The counts of neutrophils, lymphocytes, monocytes and platelets, and the concentrations of sAlb and haemoglobin were determined from pre-operative blood sampling to extrapolate the SIRI, NLR, PLR and LMR. SIRI was calculated according to the following formula: SIRI = monocyte × neutrophil/lymphocyte.…”

Section: Patient Characteristicsmentioning

confidence: 99%

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Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Zhang

et al. 2019

ANZ Journal of Surgery

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Background Our propensity score‐matching (PSM) study evaluated the prognostic significance of systemic inflammation response index (SIRI) for patients undergoing video‐assisted thoracoscopic surgery lobectomy for non‐small‐cell lung cancer (NSCLC). Methods This study was conducted on prospectively maintained database in our institution between December 2013 and March 2015. Pre‐operative SIRI was calculated by peripheral monocyte × neutrophil/lymphocyte counts. Survival analysis was performed to distinguish differences in post‐operative survival between patients stratified by an optimum cut‐off of SIRI. Multivariable Cox proportional hazards regression models were established to determine independent prognostic factors. Results There were 390 patients with resected NSCLC included. A SIRI of 0.99 was identified as the optimum cut‐off regarding to post‐operative survival. Both overall survival (OS) and disease‐free survival (DFS) in patients with SIRI >0.99 were significantly shortened than those in patient with SIRI ≤0.99. Patients with SIRI >0.99 had significantly lower rates of OS and DFS compared to those patients with SIRI ≤0.99. These differences still remained significant after subgroup analyses and PSM analyses. Multivariable analyses on the entire cohort and the PSM cohort commonly demonstrated that high pre‐operative SIRI could be an independent prognostic factor for unfavourable OS and DFS of NSCLC. Conclusions SIRI serves as a novel risk stratification tool to refine prognostic prediction for surgically resected NSCLC. SIRI may help surgeons to screen high‐surgical‐risk patients and formulate individualized treatment schemes.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Follow-up Investigationmentioning

confidence: 99%

Section: Patient Characteristicsmentioning

confidence: 99%

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Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Zhang

et al. 2019

ANZ Journal of Surgery

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Predictive value of pretreatment albumin‐to‐alkaline phosphatase ratio for overall survival for patients with advanced non‐small cell lung cancer

et al. 2020

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Objectives To investigate the relation between AAPR and OS in patients with advanced non‐small cell lung cancer (NSCLC). Methods A retrospective cohort study was conducted with 808 patients with advanced NSCLC who were treated in Guangxi Medical University Affiliated Tumor Hospital in China from 5 March 2009 to 31 August 2018. The target‐independent and dependent variables were AAPR measured in patients before anticancer treatment and overall survival (OS), respectively. Covariates involved in this study included age, gender, ECOG status, smoking history, clinical stages, pathological type, driver mutation (EGFR or ALK), metastasis or not (bone, lung, liver, brain, malignant plural effusion, and other organs), number of organ metastasis(≤3, >3), first‐line regiment and number of treatment lines (≤3, >3). Results The mean age of the selected patients was 58.3 ± 10.9 years and 68.6% were male. We divided patients according to their AAPR into low (AAPR < 0.34, n = 266), medium (AAPR = 0.34‐0.47, n = 259), and high (AAPR > 0.47, n = 283) tertile groups. Medium and high AAPR were associated with a decreased risk of death after fully adjusted Cox proportional hazard model(s) with hazards ratio (HR) 0.77 (95%CI = 0.58‐1.03) and HR 0.59 (95%CI = 0.45‐0.78), respectively (P for trend <.05). The median OS of low, medium, and high AAPR was 9.3, 11.8, and 16.9 months, respectively (P value <.0001). No optimal cutoff value of AAPR for prognosing OS was identified by smooth curve fitting. The HR and the 95% confidence intervals of the left and right sides of the inflection point 0.6 as cutoff value were 0.28 (95%CI = 0.14‐0.57) and 0.77 (95%CI = 0.34‐1.73), respectively (P value = .127). By subgroup analysis, similar results were consistently observed across nearly all the subgroups. Conclusion Our study implied that pretreatment AAPR can be used as an independent prognostic factor in patients with advanced NSCLC. This ratio should be applied for risk stratification and clinical decision‐making in those patients.

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Alkaline phosphatase combines with CT factors for differentiating small (≤ 4 cm) fat-poor angiomyolipoma from renal cell carcinoma: a multiple quantitative tool

et al. 2023

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Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator for patients undergoing minimally invasive lung cancer surgery: Propensity score matching analysis using a prospective database

Cited by 43 publications

References 35 publications

Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Predictive value of pretreatment albumin‐to‐alkaline phosphatase ratio for overall survival for patients with advanced non‐small cell lung cancer

Alkaline phosphatase combines with CT factors for differentiating small (≤ 4 cm) fat-poor angiomyolipoma from renal cell carcinoma: a multiple quantitative tool

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