Alcaloides aporfínicos con actividad antituberculosa aislados de Ocotea discolor Kunth (Lauraceae)

Murillo, Mónica Constanza Ávila; Melo, Lady Tatiana Albarracin; Suárez, Luís Enríque Cuca; Patiño-Ladino, Oscar J.; Vasquez, Juan David Guzman; McHugh, Timothy D.; Begum, Neelu

doi:10.15446/rev.colomb.quim.v46n3.62963

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Mart., Mauritia flexuosa L.f., Phoenix dactylifera L., Paludosa phoenix Roxb., and Ravenea rivularis Jum. & H.Perrier (Ávila et al, 2011;Matias et al, 2019;Mohammed and Fouad, 2022). Anthraquinones had only been described for A. aculeata.…”

Section: Discussionmentioning

confidence: 99%

Chemical constituents and antifungal potential of Attalea geraensis Barb. Rodr. (Arecaceae) palm leaves, a species native to the Cerrado of Brazil

et al. 2023

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Fungal diseases, especially those that affect the root systems of plants, caused by Rhizoctonia and Macrophomina are limiting factors for achieving high crop yields. Alternatives to controlling fungi with chemical products drive the search for new options for bioactive compounds from plants. Attalea geraensis, a palm tree from the Brazilian Cerrado, is rich in flavonoids with antifungal actions. The objective of this work is to identify the chemical classes present in the ethanolic extract of green leaves of A. geraensis and determine the antifungal potential of the extract against isolates of Macrophomina phaseolina (Tassi) Goid. and Rhizoctonia solani JG Kühn. Phytochemical prospection, flavonoid dereplication, and antifungal activity were carried out of the ethanolic extract of the green leaves of A. geraensis harvested in the Cerrado area of Brazil. Steroids, triterpenes, saponins, and anthraquinones are described here for the first time for the leaves of A. geraensis. The flavonoids quercetin, isorhamnetin, 3,7-dimethylquercetin, quercetin 3-galactoside, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one, rhamnazin 3-galactoside, keioside, and rhamnazin 3-rutinoside were identified. Of these, only quercetin and isorhamnetin had already been identified in the leaves of A. geraensis. The results show a fungistatic potential for the species. The diversity of flavonoids present in the leaves of A. geraensis may be the result of a synergistic action between fungus and plant or there could be an antagonistic effect between flavonoids and the other identified chemical classes.

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Section: Discussionmentioning

confidence: 99%

Chemical constituents and antifungal potential of Attalea geraensis Barb. Rodr. (Arecaceae) palm leaves, a species native to the Cerrado of Brazil

et al. 2023

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Preclinical Trial of Ocotea puberula (Rich.) Nees (“Canela‐Guaicá”) in Wound Healing: Validation of a Traditional Medicine Practice Used by Indigenous Groups in Southern Brazil

Arcaro

Koga

Lipinski

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. “Canela-guaicá,” “guaicá,” or “canela-sebo” [Ocotea puberula (Rich.) Nees] is a native species that is traditionally used by Kaingang indigenous groups for wound healing in southern Brazil. The aim of this study was to extract the mucilage from O. puberula barks, perform its phytochemical and physicochemical characterization, and investigate its healing potential. Methods. A murine wound model was used as a preclinical trial for authentication of the traditional knowledge from Kaingang indigenous communities. Results. Alkaloids and polysaccharides were identified by usual qualitative reactions and Fourier-transform infrared spectroscopy. This natural product showed thermal stability and pseudoplastic properties that were considered suitable for the intended use. A higher initial exacerbation of inflammatory response after 7 days, an improved angiogenesis after 14 days, and an increased wound shrinkage after 21 days were statistically significant for the “canela-guaicá” bark extract in the preclinical trial when compared to the silver calcium alginate dressing (positive control). Conclusion. The healing potential of the “canela-guaicá” bark extract, traditionally used by the Kaingang indigenous community from southern Brazil, was preclinically validated. This study paves the way for designing novel wound dressings containing this natural product in order to treat acute and chronic wounds.

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Alcaloides aporfínicos con actividad antituberculosa aislados de Ocotea discolor Kunth (Lauraceae)

Cited by 2 publications

References 32 publications

Chemical constituents and antifungal potential of Attalea geraensis Barb. Rodr. (Arecaceae) palm leaves, a species native to the Cerrado of Brazil

Chemical constituents and antifungal potential of Attalea geraensis Barb. Rodr. (Arecaceae) palm leaves, a species native to the Cerrado of Brazil

Preclinical Trial of Ocotea puberula (Rich.) Nees (“Canela‐Guaicá”) in Wound Healing: Validation of a Traditional Medicine Practice Used by Indigenous Groups in Southern Brazil

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