Alcohol and cancer: a review for psycho-oncologists

Lundberg, Jeremy C.; Passik, Steven D.

doi:10.1002/(sici)1099-1611(199712)6:4<253::aid-pon276>3.0.co;2-3

Cited by 29 publications

(7 citation statements)

References 61 publications

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“…The overall prevalence rate of cigarette use by American adults is 25% 32. Some have proposed a link between smoking and the hematoproliferative malignancies, and alcohol's role as a carcinogen has been documented 33–36. Although it is speculative, cigarette smoking and alcohol use by the participants may account for the observation that their mean age is nearly 1 decade less than the usual age of CML onset.…”

Section: Discussionmentioning

confidence: 99%

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Chang

Orav

McNamara

et al. 2004

Cancer

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BACKGROUND The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of this study was to evaluate psychosocial predictors of long‐term survival and disease recurrence after patients underwent allogeneic HSCT for chronic myelogenous leukemia (CML). METHODS In this prospective cohort study, 114 adults were admitted for allogeneic HSCT to the Brigham and Women's Hospital between July, 1997 and January, 2002. The median follow‐up was 882 days, and serial measures were taken for mood and substance use 6 months and 12 months posttransplantation. RESULTS With a 93% participation rate by all potentially eligible patients and with < 3% of patients loss to follow‐up, univariate predictors of long‐term survival and recurrence were identified. Cox proportional hazards regression models for survival and recurrence were developed. Depressive symptoms, as measured by the most recent Beck Depression Inventory (BDI), increased the risk of death by 7% for each point increase in the BDI score (P = 0.006). Fourteen of 17 patients who developed recurrent disease were cigarette smokers with an average of 22.3 pack‐years. For each pack‐year of cigarette smoking, the risk of recurrence increased by 1.7% (P = 0.01). CONCLUSIONS This study assessed the role of psychosocial variables prospectively among a clinically homogeneous but representative cohort of patients who underwent allogeneic HSCT. Although additional confirmatory studies are pending, it appears that depressive symptoms posttransplantation and cigarette smoking prior to transplantation affect outcomes adversely and may represent opportunities to improve the morbidity and mortality associated with HSCT for patients with CML. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Chang

Orav

McNamara

et al. 2004

Cancer

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“…In einem Review werden Prä-valenzraten für eine Alkoholabhängig-keit bei onkologischen Patienten von 3 bis 12% berichtet. Sie war hier häufig mit dem Vorhandensein weiterer psychischer Störungen assoziiert [35]. Eine Studie an einer Stichprobe von Krebspatienten, die anhand eines klinischen Interviews befragt wurden, zeigt Präva-lenzraten für eine Nikotin-und/oder Alkoholabhängigkeit von 2,5% [4].…”

Section: Suchterkrankungenunclassified

Psychische Komorbidität bei Krebserkrankungen

Weis

Boehncke

2010

Bundesgesundheitsbl.

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In western industrial nations, cancer is one of the most frequent somatic diseases showing increasing incidence rates. Although the options for medical treatment and the survival rates for most cancer diagnoses have improved over the last few decades, cancer is still a life-threatening illness associated with psychosocial issues, suffering, and distress. Depending on the severity and duration of symptoms, psychosocial distress due to cancer ranges from normal reactions to psychological comorbidity based on ICD classification criteria. In cancer patients, the most frequent psychological diagnoses are adjustment disorders, anxiety, and depression; prevalence rates in the literature show high variations depending on the tumor type studied and the assessment instrument used. Today, standardized and validated screening instruments and diagnostic interviews are available for the screening and assessment of psychosocial distress and psychiatric comorbidity. The screening of psychosocial distress in cancer patients and the assessment of psychiatric disorders are important tasks of modern cancer treatment in order to determine the need for psychosocial counseling and psychooncological treatment.

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“…This risk may be partly due to secondary factors such as less healthy lifestyle choices, smoking and excessive alcohol consumption (10). These lifestyle factors are also associated with an increased risk of cancer, especially tobacco and alcohol use in head and neck cancer (11–13). The question remains whether, once these secondary factors have been taken into account, depression independently increases the risk of cancer?…”

Section: Mood and Malignancy: Head And Neck Cancer And Depressionmentioning

confidence: 99%

Mood and malignancy: head and neck cancer and depression

Archer

Hutchison²,

Korszun

2008

J Oral Pathology Medicine

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Head and neck cancer patients have been reported to show high rates of depression. However, it is important to differentiate between depressive symptoms and a depressive disorder. This review critically examines the relationship between head and neck cancer and depression. There appears to be little evidence for depression leading to an increased risk of developing cancer and although depressive symptoms in head and neck cancer patients are common, very few studies have investigated depressive disorders. The studies that investigated the incidence of a comorbid depressive disorder report a prevalence very close to that of the general population, implying that major depression is not a normal response to cancer. Finally, the evidence suggests that comorbidity of depression with cancer has a negative impact on morbidity and mortality. Both psychosocial and biological factors could account for this. Dysregulation of the stress hormone axis and increased inflammation are common in depressive disorders and have been suggested as underlying pathological mechanisms and are both markers of poor prognosis in cancer. This evidence suggests that a relatively small number of patients develop a depressive disorder following a diagnosis of cancer, but for those that do it may have a substantial impact on their prognosis.

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Alcohol and cancer: a review for psycho-oncologists

Cited by 29 publications

References 61 publications

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Psychische Komorbidität bei Krebserkrankungen

Mood and malignancy: head and neck cancer and depression

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