Alcohol and Cancer: Epidemiology and Biological Mechanisms

Rumgay, Harriet; Murphy, Neil; Ferrari, Pietro; Soerjomataram, Isabelle

doi:10.3390/nu13093173

Cited by 192 publications

(105 citation statements)

References 41 publications

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“…Oxidative stress results from an imbalance in the redox system, and alcohol can cause oxidative stress ( Kang et al, 2021 ; Lopatynska-Mazurek et al, 2021 ; Rumgay et al, 2021 ). Nrf2 plays an important role in antioxidation by reducing oxidative stress and inflammation and protecting cells by regulating antioxidant enzyme activities through the antioxidant damage pathway.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress

Zhang

et al. 2022

Front. Neurosci.

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BackgroundLong-term alcohol exposure is associated with oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation, which may impair cognitive function. Probiotics supplements can significantly improve cognitive function in neurodegenerative diseases such as Alzheimer’s disease. Nevertheless, the effect of Lactobacillus plantarum ST-III culture supernatant (LP-cs) on alcohol-induced cognitive dysfunction remains unclear.MethodsA mouse model of cognitive dysfunction was established by intraperitoneal injection of alcohol (2 g/kg body weight) for 28 days. Mice were pre-treated with LP-cs, and cognitive function was evaluated using the Morris water maze test. Hippocampal tissues were collected for biochemical and molecular analysis.ResultsLP-cs significantly ameliorated alcohol-induced decline in learning and memory function and hippocampal morphology changes, neuronal apoptosis, and synaptic dysfunction. A mechanistic study showed that alcohol activated protein kinase R-like endoplasmic reticulum kinase (PERK) signaling and suppressed brain derived neurotrophic factor (BDNF) levels via ER stress in the hippocampus, which LP-cs reversed. Alcohol activated oxidative stress and inflammation responses in the hippocampus, which LP-cs reversed.ConclusionLP-cs significantly ameliorated alcohol-induced cognitive dysfunction and cellular stress. LP-cs might serve as an effective treatment for alcohol-induced cognitive dysfunction.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress

Zhang

et al. 2022

Front. Neurosci.

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“…A correlation between the tumor macroenvironment and the incidence of cancer has been reported. Pathologically and epidemiologically, the correlation patterns differ according to the type of carcinoma [ 34 , 35 , 36 ]. In diabetes, insulinemia and hyperglycemia are induced, initiating carcinogenesis.…”

Section: Integrated Interpretation: Tissue Specificity and Environmen...mentioning

confidence: 99%

New Drug Development and Clinical Trial Design by Applying Genomic Information Management

Gim

2022

Pharmaceutics

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Depending on the patients’ genotype, the same drug may have different efficacies or side effects. With the cost of genomic analysis decreasing and reliability of analysis methods improving, vast amount of genomic information has been made available. Several studies in pharmacology have been based on genomic information to select the optimal drug, determine the dose, predict efficacy, and prevent side effects. This paper reviews the tissue specificity and genomic information of cancer. If the tissue specificity of cancer is low, cancer is induced in various organs based on a single gene mutation. Basket trials can be performed for carcinomas with low tissue specificity, confirming the efficacy of one drug for a single gene mutation in various carcinomas. Conversely, if the tissue specificity of cancer is high, cancer is induced in only one organ based on a single gene mutation. An umbrella trial can be performed for carcinomas with a high tissue specificity. Some drugs are effective for patients with a specific genotype. A companion diagnostic strategy that prescribes a specific drug for patients selected with a specific genotype is also reviewed. Genomic information is used in pharmacometrics to identify the relationship among pharmacokinetics, pharmacodynamics, and biomarkers of disease treatment effects. Utilizing genomic information, sophisticated clinical trials can be designed that will be better suited to the patients of specific genotypes. Genomic information also provides prospects for innovative drug development. Through proper genomic information management, factors relating to drug response and effects can be determined by selecting the appropriate data for analysis and by understanding the structure of the data. Selecting pre-processing and appropriate machine-learning libraries for use as machine-learning input features is also necessary. Professional curation of the output result is also required. Personalized medicine can be realized using a genome-based customized clinical trial design.

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“…It is also important to mention that the population had low socioeconomic status, unbalanced eating habits, and considerable alcohol consumption. Alcohol consumption can cause DNA damage and is considered a risk factor for cancer Rumgay et al, 2021).…”

Section: )mentioning

confidence: 99%

Analysis of the Cytotoxic and Genotoxic Effects in a Population Chronically Exposed to Coal-Mining Residues

León-Mejía¹,

Rueda

Pérez

et al. 2022

Preprint

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During coal-mining activities, many compounds are released into the environment that can negatively impact human health. Particulate matter, polycyclic aromatic hydrocarbons (PAHs), metals, and oxides are part of the complex mixture that can affect nearby populations. Therefore, this study was designed to evaluate the potential cytotoxic and genotoxic effects of coal residues on peripheral blood lymphocytes and buccal cells in individuals chronically exposed to them. We recruited 150 individuals who lived more than 20 years in the Loma-Colombia and 120 control individuals from the city of Barranquilla without a history of exposure to coal-mining. In cytokinesis-block micronucleus cytome (CBMN-Cyt) assay, signi cant differences in the frequency of micronucleus (MN), nucleoplasmic bridge (NPB), nuclear bud (NBUD), and apoptotic cells (APOP) were observed between the two groups. In buccal micronucleus cytome (BM-Cyt) assay, a signi cant formation of NBUD, karyorrhexis (KRX), karyolysis (KRL), condensed chromatin (CC), and binucleated (BN) cells was observed in the exposed group. Considering sociodemographic factors, a signi cant correlation was found between CBMN-Cyt-NBUD and vitamin consumption and between CBMN-Cyt-MN and CBMN-Cyt-APOP and meat consumption. Moreover, a signi cant correlation was found between BM-Cyt-KRL and vitamin consumption. Using Raman spectroscopy, a signi cant increase in the concentration of DNA/RNA bases, creatinine, polysaccharides and fatty acids was detected in the urine of individuals exposed to coal-mining compared to the control group. These results contribute to the discussion on the effects of coal-mining on nearby populations and the development of diseases due to chronic exposure to these residues.

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Alcohol and Cancer: Epidemiology and Biological Mechanisms

Cited by 192 publications

References 41 publications

Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress

Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress

New Drug Development and Clinical Trial Design by Applying Genomic Information Management

Analysis of the Cytotoxic and Genotoxic Effects in a Population Chronically Exposed to Coal-Mining Residues

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