Alcohol and Malnutrition in the Pathogenesis of Liver Disease

Lieber, Charles S.

doi:10.1001/jama.1975.03260100047019

Cited by 38 publications

(4 citation statements)

References 24 publications

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“…Malnutrition has previously been associated with AC development [58][59][60]. In fact, malnutrition also results when alcohol consumption exceeds 30% of daily caloric intake [27].…”

Section: Discussionmentioning

confidence: 99%

The role of FABP2 gene polymorphism in alcoholic cirrhosis

Salguero

Leon

Santos

et al. 2005

Hepatology Research

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“…Malnutrition has previously been associated with AC development [58][59][60]. In fact, malnutrition also results when alcohol consumption exceeds 30% of daily caloric intake [27].…”

Section: Discussionmentioning

confidence: 99%

The role of FABP2 gene polymorphism in alcoholic cirrhosis

Salguero

Leon

Santos

et al. 2005

Hepatology Research

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“…Model studies confirmed that excessive alcohol consumption contributes more to liver disease relative to metabolic factors [35]. Alcohol can cause direct toxic damage to the liver, leading to hepatitis, cirrhosis, and even liver cancer [36]. In the multivariate analysis, we corrected for the effects of other covariates and found a significant correlation between alcohol consumption and the risk of liver dysfunction.…”

Section: Table 4 Logistic Regression Analysis Of the Interactive Item...mentioning

confidence: 75%

Combined impact of alcohol consumption and metabolic syndrome on liver dysfunction in an elderly Chinese population

Zhao,

Yuan,

Lin

et al. 2024

Diabetol Metab Syndr

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Alcohol consumption and metabolic syndrome(MetS), both prevalent in the general population, frequently co-occur. They are recognized as significant contributors to liver dysfunction, yet their combined effect is often challenging to delineate. This study delves into the compounding influence of alcohol consumption and metabolic disorder on liver dysfunction within an elderly demographic in Zhejiang Province, China. Our findings spotlight a heightened risk of liver dysfunction among females, younger individuals, rural dwellers, those with minimal educational attainment, single individuals, and those diagnosed with MetS. We also discerned a positive correlation correlation between the number of MetS components and the propensity for liver dysfunction. Furthermore, the risk of liver dysfunction escalated in tandem with the frequency of alcohol consumption. Interestingly, a prolonged abstinence period (≥ 5 years) seemed to mitigate this risk. Our research underscores the significance of refraining from excessive alcohol consumption, embracing a healthy lifestyle, and managing MetS components-especially triglyceride levels-for effective prevention of liver dysfunction.

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“…This malnutrition has been associated with impaired GI absorption of nutrients in consumers, as well as drug-induced changes in food-intake preferences and behaviors, which contribute to unhealthy weight fluctuation and nutrient deficiency. Alcohol, particularly chronic alcohol consumption in adults has long been associated with malnutrition [for example, documented in early studies by Lieber (1975) ]. Notably, changes in nutritional levels are directly associated with immune function, with poor nutrition serving as the leading cause of immunodeficiency worldwide ( Chandra, 1997 ).…”

Section: Nutrition As a Driver And Consequence Of Pae-altered Microbiotamentioning

confidence: 99%

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure

Upreti,

Rouzer,

Bowring

et al. 2023

Front. Neurosci.

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Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alcohol exposure (PAE) also results in persistent inflammation and nutrition deficiencies, though research on the impact of PAE on the enteric microbiota is in its infancy. Importantly, other neurodevelopmental disorders, including autism spectrum and attention deficit/hyperactivity disorders, have been linked to gut microbiota dysbiosis. The combined evidence from alcohol exposure in adulthood and from other neurodevelopmental disorders supports the hypothesis that gut microbiota dysbiosis is likely an etiological feature that contributes to negative developmental, including neurodevelopmental, consequences of PAE and results in fetal alcohol spectrum disorders. Here, we highlight published data that support a role for gut microbiota in healthy development and explore the implication of these studies for the role of altered microbiota in the lifelong health consequences of PAE.

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Alcohol and Malnutrition in the Pathogenesis of Liver Disease

Cited by 38 publications

References 24 publications

The role of FABP2 gene polymorphism in alcoholic cirrhosis

The role of FABP2 gene polymorphism in alcoholic cirrhosis

Combined impact of alcohol consumption and metabolic syndrome on liver dysfunction in an elderly Chinese population

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure

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