The role of FABP2 gene polymorphism in alcoholic cirrhosis

Association of the T54 allele of the FABP2 gene with cardiovascular risk factors in obese Mexican subjects

“…7 The TT and AT subjects were grouped during the analysis. The differences between subjects in the AA and AT/TT groups are shown in table 1.…”

Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

“…In the context of this study, the genetic architecture of the Mexican population is characterized by an admixture of three paternal lineages consisting of Amerindian, European (Caucasian) and African ancestry, denoted as Mestizos, with an unequal inter-regional distribution [ 30 , 31 , 32 , 33 ]. Therefore, among the Mexican population, it is expected that the distribution of the risk and protector alleles of certain lipid transporters, taste receptors and metabolizing enzymes may vary due to the degree of ancestral inheritance and prevalence of regional environmental factors [ 34 , 35 , 36 , 37 , 38 , 39 ]. In this study, the Val/Val risk genotype was prevalent in 5.7% among the studied population of West Mexico.…”

“…Studies on the TAS1R2 receptor have focused on the effects of its genetic variations on sweet taste perception [ 40 ], sugar or carbohydrate intake per se [ 24 , 39 , 40 ] and the prevalence of dental caries in children and adults [ 41 , 42 , 43 ], whereas the association with dyslipidemia have been less explored in humans. In this study, we highlight the association of the Val/Val genotype with a higher carbohydrate intake and HTG among a Mestizo population of West Mexico.…”

“…This complex diversity is notable when revising studies that report divergent results. For example, an association between the rs12033832 (G>A) SNP with higher sucrose taste thresholds and sugar intake in overweight subjects was recently documented [ 39 ]; whereas, for the rs35874116 SNP, a lower carbohydrate intake among Val allele carriers in comparison to the Ile homozygotes was reported in Canadian subjects [ 24 ]. Moreover, these discrepancies may also be caused by ethnic differences between populations, gene-environment interactions, study design, mode of inheritance and food culture [ 47 ].…”

Association of the ε2 Allele of Apoe Gene to Hypertriglyceridemia and to Early‐Onset Alcoholic Cirrhosis

“…By contrast, the APOE*4 allele predominated in the non‐H patients and with more than 20 years of alcohol abuse. Recently we have suggested that in spite of the presence of a marginal diet and an excessive consumption of ethanol, alcoholic cirrhotic patients may be partially protected from the oxidative stress and lipid peroxidation due to the presence of Thr54 variant of the FABP2 gene that promotes the absorption of more saturated fatty acids (Salguero et al., 2005).…”