Alcohol and Substance Abuse among Schizophrenic Patients Presenting to an Emergency Psychiatric Service

Barbee, James G.; Clark, Peter; Crapanzano, Michael S.; Heintz, Gerald C.; Kehoe, Catharine E.

doi:10.1097/00005053-198907000-00003

Cited by 169 publications

(114 citation statements)

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“…Patients with schizophrenia show alarmingly high rates of substance use disorders (20-65%) [308][309][310][311][312][313], as well as a considerably greater risk of developing a drug addiction disorder than individuals in the general population [314]. As reviewed in detail elsewhere [315], dually diagnosed schizophrenia patients typically present with more severe symptoms [308,309,[316][317][318][319], exhibit increased suicidal ideation [320,321], require more frequent hospitalizations [310,322], and experience more frequent relapses than patients without co-occurring substance abuse [323][324][325].…”

Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

“…As reviewed in detail elsewhere [315], dually diagnosed schizophrenia patients typically present with more severe symptoms [308,309,[316][317][318][319], exhibit increased suicidal ideation [320,321], require more frequent hospitalizations [310,322], and experience more frequent relapses than patients without co-occurring substance abuse [323][324][325]. While analyses for polymorphisms in the Homer genes have not yet been assessed in a co-morbid population, single nucleotide polymorphisms in Homer1 have been associated with cocaine addiction [241], as well as in schizophrenia (IVS4 + 18A > G in intron 4) [326].…”

Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

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Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

View full text Add to dashboard Cite

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“…En un estudio realizado en un servicio de urgencias de un hospital general se observó cómo en cerca del 50% de los esquizofrénicos que fueron atendidos referían abuso o dependencia de alcohol y/u otras sustancias psicotóxicas, principalmente cánnabis (Barbee, 1989). Dos han sido los patrones fundamentales de consumo de sustancias psicotóxicas que se han distinguido en pacientes esqizofrénicos: aquellos sujetos consumidores únicamente de alcohol y cánnabis, y aquellos pacientes policonsumidores que lo son también de estas dos sustancias (Cuffel, 1993).…”

Section: ¿Afecta El Cánnabis Al Curso De La Esquizofrenia?unclassified

Development of CIE-10 and DSM-IV cannabis disorders / Desarrollo de la CIE-10 y el DSM-IV para trastornos por cánnabis

Puig¹

2003

HAAJ

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RESUMENLa CIE-10 y el DSM-IV presentan, con pocas diferencias, la misma clasificación para los trastornos psiquiátricos por consumo de sustancias. Como ambos instrumentos diagnósticos son meras estructuras, se intenta desarrollar su contenido para los trastornos psiquiátricos relacionados con el cánnabis. Se enfatiza el debate cánnabis-esquizofrenia.Palabras clave: cánnabis, psiquiatría, DSM-IV, CIE-10 ABSTRACT ICD-10 and DSM-IV present, with few differences, the same classification for substance abuse psychiatric disorders. Since both diagnostic instruments are merely structures, a temptative devolopment of content for cannabis-related psychiatric disorders is given. The cannabis-schizophrenia debate is emphasised.

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Section: ¿Afecta El Cánnabis Al Curso De La Esquizofrenia?unclassified