Alcohol, cancer, and immunomodulation

Mufti, Siraj I.; Darban, Hamed R.; Watson, Ronald R.

doi:10.1016/s1040-8428(89)80003-4

Cited by 34 publications

(18 citation statements)

References 106 publications

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“…Although high alcohol ingestion, either episodically or on a regular basis, is regarded as immunosuppressive (MacGregor, 1986;Mufti et al, 1989), less is known about the immunomodulation effects of light-to-moderate alcohol consumption (i.e. social drinking).…”

Section: Discussionmentioning

confidence: 99%

“…social drinking). Moderate, social alcohol use could potentially either suppress or enhance the induction and growth of cancers through its effect on membrane fluidity or composition (Freund, 1979;Mufti et al, 1989). The effect of altered membrane composition on lymphocytes remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Alcohol may be immunomodulatory as several host defense factors have been implicated in the increased incidence of infectious diseases observed in alcohol abusers (Mufti et al, 1989;MacGregor, 1986). However, the role of moderate alcohol use on the immune system is less clear (Mufti et al, 1989), and the role of moderate alcohol consumption in the aetiology of NHL has received only limited attention.…”

mentioning

confidence: 99%

“…However, the role of moderate alcohol use on the immune system is less clear (Mufti et al, 1989), and the role of moderate alcohol consumption in the aetiology of NHL has received only limited attention. Among eight reports from five case-control studies that have assessed this association, one found a significant positive association (De Stefani et al, 1998), five reported no association (Cartwright et al, 1988;Franceschi et al, 1989aFranceschi et al, , 1989bTavani et al, 1994Tavani et al, , 1997, one showed a weak inverse association (Brown et al, 1992) and one found a significant inverse association (Nelson et al, 1997).…”

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confidence: 99%

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Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Chiu

Cerhan²,

Gapstur

et al. 1999

Br J Cancer

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SummaryWe investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 35 156 lowa women aged 55-69 years who participated in the lowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL (P-trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day -1 (RR = 0.78; 95% confidence interval (CI) 0.51-1.21) and > 3.4 g day -1 (RR = 0.59; 0.36-0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker; 0.05-0.86; P-trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26-0.90; P-trend = 0.01) and low-grade NHL (RR = 0.52; 0.21-1.26; P-trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Chiu

Cerhan²,

Gapstur

et al. 1999

Br J Cancer

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“…In 1985, alcohol dependency affected an estimated 10 to 11 million Americans (Mufti et al, 1989). Alcoholism is an escalating global problem also affecting developing countries, where locally brewed, often heavily contaminated, alcoholic beverages are readily available.…”

Section: Role Of Nutritionmentioning

confidence: 99%

Bionutrition and Oral Cancer in Humans

Enwonwu

Meeks

1995

Critical Reviews in Oral Biology & Medicine

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Tobacco (smoking and smokeless) use and excessive consumption of alcohol are considered the main risk factors for oral cancer . Conspicuous national and international variations in oral cancer incidence and mortality rates, as well as observations in migrant populations, raise the possibility that diet and nutritional status could be an important etiologic factor in oral carcinogenesis. As shown in this report, abuse of alcohol and tobacco has serious nutritional implications for the host, and generates increased production of reactive free radicals as well as eliciting immunosuppression. Maintenance of optimal competence of the immune system is critical for cancer surveillance. Active oxygen species and other reactive free radicals mediate phenotypic and genotypic alterations that lead from mutation to neoplasia. Consequently, the most widely used chemopreventive agents against oral cancer (e.g., vitamins A, E, C, and p-carotene) are anti-oxidants/free radical scavengers. These anti-oxidants, both natural and synthetic, neutralize metabolic products (including reactive oxygen species), interfere with activation of procarcinogens, prevent binding of carcinogens to DNA, inhibit chromosome aberrations, restrain replication of the transformed cell, suppress actions of cancer promoters, and may even induce regression of precancerous oral lesions such as leukoplakia and erythroplakia. Malnutrition is characterized by marked tissue depletion of anti-oxidant nutrients, including GSH (y-glutamyl-cysteinyl-glycine), a key cellular anti-oxidant as well as a modulator of T-cell activation. GSH or its precursor cysteine inhibits activation of the nuclear transcription factor kB (NFkB), and has been shown to be protective against chemically induced oral cancer and leukoplakia. Alcohol-, tobacco-, and/or malnutrition-induced immunosuppression promotes impaired salivary gland function and oral mucosal immunity, a prominent reduction in the number of helper CD4 cells with less marked changes in number of suppressor T-cells, and depressed NK cell activity, among others. These suggest a breakdown in the capacity of the malnourished to mount effective tumor surveillance. This review article underscores the compounding but important roles of nutritional/dietary factors in the long-established causal link between abuse of alcohol and tobacco (smoking and smokeless) and oral cancer.

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Effect of alcohol drinking and cigarette smoking on neutrophil functions in adults

et al. 2011

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In recent years, the effects of smoking and excessive alcohol consumption on immune function have been studied, due to a high prevalence of infection or cancer in heavy drinkers, and the combination of smoking and drinking was considered to be a carcinogenic risk. However, the effect of smoking and drinking on systemic immune function has yet to be clearly understood. In this study, we investigated neutrophil functions (reactive oxygen species (ROS) productive activity, phagocytic ability and serum opsonic activity) and their relationship with alcohol consumption or amount of smoking. In total there were 731 male and female adult subjects who participated in the Iwaki Health Promotion Project in 2005. Multiple regression analysis showed a trend of increased ROS production in male subjects and a statistically significant decrease was observed in phagocytic activity caused by smoking in female subjects. In other words, oxidative stress caused by smoking in male subjects may be involved in ROS production from neutrophils. Decreased phagocytic activity of neutrophils caused by smoking suggests that host defense functions were impaired in female subjects. A relationship between neutrophil functions and the amount of alcohol consumption was not observed.

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Alcohol, cancer, and immunomodulation

Cited by 34 publications

References 106 publications

Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Bionutrition and Oral Cancer in Humans

Effect of alcohol drinking and cigarette smoking on neutrophil functions in adults

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