Alcohol Consumption and Incident Stroke Among Older Adults

Cunningham, Solveig A.; Mosher, Aleena; Judd, Suzanne E.; Matz, Melissa; Kabagambe, Edmond K.; Moy, Claudia S.; Howard, Virginia J.

doi:10.1093/geronb/gbw153

Cited by 21 publications

(14 citation statements)

References 48 publications

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“…Quitting smoking limits the destruction of the periodontal tissues and leads to better clinical results [ 78 ]. Alcohol consumption is also more frequent in men who are stroke survivors compared to women [ 79 , 80 , 81 ], as in our study. The risk for periodontitis among men reporting regular alcohol intake previously proved dose-dependency [ 82 ].…”

Section: Discussionsupporting

confidence: 74%

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Stănescu

Bulboacă

Micu

et al. 2020

JCM

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Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first IS within less than six weeks who were able to undergo periodontal examinations were evaluated. Demographic data, periodontal status, oxidative stress parameters/plasma antioxidant capacity, and C-reactive protein in patients who suffered a recent large artery atherosclerosis ischemic stroke were reccorded. Results: 93 patients were included in the study. More men were smokers (12/57 vs. 3/36) and consumed alcohol (17/57 vs. 3/36), and more women had higher glycemic values (p = 0.023), total cholesterol (p < 0.001), LDL (low-density lipoprotein)-cholesterol (p = 0.010), and HDL (high-density lipoprotein)-cholesterol (p = 0.005) levels. Significantly more men than women had moderate plus severe periodontal disease (p = 0.018), significantly higher levels of nitric oxide (p = 0.034), and significantly lower levels of total antioxidant capacity (p = 0.028). Conclusions: In this pilot study, men seem to be more prone to oxidative stress and to develop more severe forms of periodontitis among patients with stroke, but the results need validation on a larger sample.

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Section: Discussionsupporting

confidence: 74%

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Stănescu

Bulboacă

Micu

et al. 2020

JCM

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“…Additionally, incidence of prefrailty in the FP-population was 34.4%. The difference between the two measures is considerable but consistent with published literature [ 39 , 40 ]. The meta-analysis on frailty incidence reported 4.6% pooled incidence of frailty among robust older adults aged 60 years and older during a median follow-up of three years.…”

Section: Discussionsupporting

confidence: 90%

“…Non-hazardous and hazardous alcohol use in old age showed decreased frailty risk compared to no alcohol use, even after adjustment for baseline disease and medication use; however, hazardous alcohol use showed smaller decrease than non-hazardous alcohol use (adjusted OR (95% CI): 0.68 (0.60-0.77) for nonhazardous use and 0.80 (0.68-0.93) for hazardous alcohol use). Similarly, when using frailty phenotype as the outcome measure, only non-hazardous alcohol use was associated with decreased frailty incidence, suggesting a U-shaped relationship, which has been proposed before [6,38,39]. Sub-analysis of our data using previous alcohol problems as additional cofactor showed that participants with previous alcohol problems (self-reported excessive drinking problem in the past) have significantly increased incidence of frailty compared to participants without previous alcohol problems, even after adjustment for several confounding factors.…”

Section: Discussionmentioning

confidence: 60%

The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study

2021

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Background Understanding potentially modifiable factors that influence the risk of frailty is a key concern for the management of this urgent contemporary public health challenge. This study evaluates the association between the use of various medications or alcohol and the incidence of frailty among older adults. Methods This study was a retrospective cohort study on older adults (≥ 65 years) using data from the longitudinal Survey of Health, Ageing and Retirement in Europe (SHARE survey, 28 countries). Medication use was measured as taking several different groups of medications. Alcohol use was assessed with SHARE questions corresponding to AUDIT-C. The outcome measure was the incidence of frailty after two years, defined by frailty index (FI) and frailty phenotype (FP). A multiple logistic regression model was used to evaluate the association with adjustment for several potential confounding factors. Results Of the 14,665 FI-population participants, 1800 (12.3%) developed frailty within two years. Of the 8133 FP-population participants, 2798 (34.4%) developed pre-frailty and 247 (3.0%) developed frailty within two years of baseline. After adjustment for potential confounding variables, non-hazardous alcohol use (adjusted OR; 95% CI for the FI-population: 0.68; 0.60–0.77) and hazardous alcohol use (0.80; 0.68–0.93) are associated with lower incidence of frailty compared to no alcohol use. The odds of frailty are increased when taking medications; the largest effect size was observed in older adults taking medication for chronic bronchitis (adjusted OR; 95% CI for the FI-population: 2.45; 1.87–3.22), joint pain and other pain medication (2.26; 2.00–2.54), medication for coronary and other heart disease (1.72; 1.52–1.96), medication for diabetes (1.69; 1.46–1.96), and medication for anxiety, depression and sleep problems (1.56; 1.33–1.84). Additionally, the risk of frailty was increased with stroke, Parkinson’s disease and dementia. Conclusions Taking certain groups of medication was associated with increased incidence of frailty and pre-frailty, which might be due to either medication use or the underlying disease. Alcohol use was associated with a lower risk of pre-frailty and frailty compared to no alcohol use, which might be due to reverse causality or residual confounding. There was no significant interaction effect between medication groups and alcohol use on frailty incidence.

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“…This study also found that there was no significant relationship between the consumption of alcohol and the incidence of stroke. Other study reported that alcohol consumption can increase the risk of stroke (24,25), limited subjetc that dominated by ISH in elderly in this study may influence the result (26).…”

Section: Discussionmentioning

confidence: 52%

Stroke prevalence among isolated systolic hypertension subjects in Indonesia

Pamelasari

Azam

Fibriana

et al. 2021

Preprint

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Introduction: Hypertension has been known to be a decisive factor for stroke in the elderly; however, limited studies reported stroke risk factors in subjects with isolated systolic hypertension (ISH). Methods: This cross-sectional survey was conducted using Riskesdas 2018 secondary data. Subjects aged 55 years who had a systolic blood pressure ≥140 mmHg and diastolic < 90 mmHg were included as the study sample. According to the National Institute of Health Research and Development, the Ministry of Health, Republic of Indonesia, all study variables were measured using household and individual questionnaires. The data were analyzed using the chi-square test and Fisher's test. Results: Of 3159 subjects with ISH 8.3% had a stroke, the risk factors that had a significant relationship with the prevalence of stroke (p<0.005) were gender (1,790; 1,420-2,256), smoking habits (1,645; 1,291-2,096), physical and mental stress (2,080; 1,618-2,673), area of residence (1,720; 1,331-2222), and education level (0.656; 0.515-0.835). Conclusion: Prevalence of stroke among ISH in Indonesia was 8.3%. Female with smoking habits, had mental and physical stress, liviing in urban area, and had low level eduatcion were associated with the status of stroke in ISH subjects in Indonesia.

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Alcohol Consumption and Incident Stroke Among Older Adults

Abstract: Among older adults, those who used to, but no longer, drink had higher risks of stroke, especially among women; current light drinkers had the lowest risk of stroke.

Cited by 21 publications

References 48 publications

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study

Stroke prevalence among isolated systolic hypertension subjects in Indonesia

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