Alcohol consumption and risk of colorectal cancer: the Findrink study

Abstract

We investigated the association between alcohol consumption and colorectal cancer because previous studies have yielded conflicting results. As part of the Findrink study, data from the Kuopio Ischaemic Heart Disease (KIHD) Risk Factor Study were analysed. The KIHD study is a cohort of 2,682 men from Eastern Finland with no history of cancer at baseline. The men were grouped into five groups according to their weekly alcohol intake in grams. Association between alcohol and colorectal cancer was examined using Cox proportional hazard models. There were 59 cases of colorectal cancer during an average follow up of 16.7 years. Men within the highest quintile of alcohol consumption had a median weekly alcohol intake of 198.8 g. Age and examination year adjusted risk ratio of colorectal cancer among men within the highest quintile of alcohol consumption was 4.4 (95% CI: 1.6-11.9, P-value = 0.004). After adjusting for potential confounders, such as vegetable consumption, fibre intake, smoking, family history of cancer, socio-economic status, leisure time physical activity, men with the highest amount of alcohol consumption still had a 3.5-fold (95% CI: 1.2-9.9, P-value = 0.021) increased risk of colorectal cancer. Exclusion of men diagnosed with colorectal cancer during the first 2 years of follow up from the analyses did not alter the risk increase. In conclusion, this study gives further evidence of a positive association between alcohol consumption and the risk of colorectal cancer.

Associations between polymorphisms in the SYK promoter and susceptibility to sporadic colorectal cancer in a Southern Han Chinese population - a short report

“…Studies have shown that in colorectal mucosa cells benzopyrene-DNA adducts can be detected, more frequently in smokers than in non-smokers, thus increasing the risk of CRC [23]. A correlation between alcohol consumption and an increased CRC risk has also been observed in many studies [24][25][26], whereas a high BMI has been found to act as an independent risk factor for CRC [27]. A high BMI is generally associated with metabolic disorders such as insulin resistance, hyperinsulinemia, increased insulin-like growth factor (IGF1) levels, and decreased adiponectin and insulin-like growth factor binding protein-3 (IGFBP3) levels.…”

Moderate Alcohol Consumption and Colorectal Cancer Risk

“…The discrepancies among the reports are attributed to the diverse populations evaluated, which have different alcohol concentrations for beverage types, as well as varied drinking patterns and beverage preferences (Toriola et al, 2008). The lack of uniformity in study methods has made it difficult to standardize moderate consumption throughout the reports.…”

“…However, in the current decade reports have emerged that suggest there is a nonlinear dose-dependent response for moderate alcohol consumption that is associated with a protective effect against the development of CRC (Crockett et al, 2011;Kontou et al, 2012). Other reports have indicated associations between alcohol intake and genetic variants that may account for increased CRC in certain populations (Ferrari et al, 2012;Gao et al, 2008;Toriola et al, 2008). Therefore, the purpose of this review was to evaluate the most recent evidence with respect to the potential differential effects of alcohol intake level, specific beverage type, and genetic variation on the incidence of CRC in populations throughout the world.…”

A Telematic Tool to Predict the Risk of Colorectal Cancer in White Men and Women: ColoRectal Cancer Alert (CRCA)

“…The weekly intake of servings of red wine, beer and liquor is obtained an estimate of total alcohol consumption per week[18].-IMC. Weight and Height.…”