Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case–control study

Lilla, Carmen; Koehler, Tracy J.; Kropp, Silke; Wang-Gohrke, Shan; Chang‐Claude, Jenny

doi:10.1038/sj.bjc.6602608

Cited by 23 publications

(26 citation statements)

References 17 publications

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“…The lack of a main effect for AHD1C agrees with recently published data from the Breast Cancer Association Consortium (BCAC) which found no overall association in 7,805 cases and 7,320 controls, although the association with alcohol intake was not evaluated [37]. Evidence from other studies investigating either ADH1C [27][28][29] or ADH1B [30,31], alcohol intake, and breast cancer risk has been mixed, all of which have compared breast cancer cases to unrelated controls. In this study, we examined full sisters discordant by breast cancer status to see if alcohol, and its potential modification by genotype, could contribute to differences in breast cancer risk within families.…”

Section: Discussionsupporting

confidence: 88%

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Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

Terry

Knight

Zablotska

et al. 2007

Breast Cancer Res Treat

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Moderate alcohol intake has been consistently associated with a modest (30-50%) increase in breast cancer risk, but it remains unclear if certain individuals have higher susceptibility to the harmful effects of alcohol intake. Individuals differ in their ability to metabolize alcohol through genetic differences in alcohol dehydrogenase (ADH), the enzyme that catalyzes the oxidation of approximately 80% of ethanol to acetaldehyde, a known carcinogen. Using data from the Breast Cancer Family Registry (n = 811 sister sets), we examined whether sisters with breast cancer differ with respect to alcohol consumption and alcohol metabolism (measured by polymorphisms in ADH1B and ADH1C) compared to their sisters without breast cancer. Neither alcohol drinking nor alcohol metabolizing ADH1B and ADH1C genotypes were associated with breast cancer risk. However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed.

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Section: Discussionsupporting

confidence: 88%

“…Two studies have examined the association between ADH1B genotype and breast cancer risk with inconsistent findings [30,31]. These studies compared breast cancer cases to unrelated controls.…”

mentioning

confidence: 96%

Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

Terry

Knight

Zablotska

et al. 2007

Breast Cancer Res Treat

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“…Sturmer et al 98 found that ADH1B*2 was more common in women with breast cancer, despite the fact that those with ADH1B*2 drank less. However, in Lilla et al, 99 ADH1B*2 was associated with decreased risk of breast cancer as alcohol consumption increased, while ADH1B*1 was associated with increased risk with higher alcohol consumption. Another study did not find an association between ADH1B genotype and cancer for laryngeal cancer.…”

Section: -80mentioning

confidence: 99%

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Green

Stoler

2007

American Journal of Obstetrics and Gynecology

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“…Subjects carrying copies of the fast alcohol metabolizer show a tendency towards lower alcohol consumption, in line with previous observations among Caucasian populations. [27][28][29][30] The present study also shows that polymorphisms in the rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) genes are not associated with risk of CRC or of colon or of rectal cancers in Caucasian populations. However, further analyses in the rs1573496 (ADH7) polymorphism showed that alcohol intake was associated with CRC risk among heterozygous and homozygous carriers of the rare rs1573496(C) (ADH7) allele, while among homozygous wild-type participants the alcohol CRC association was weak.…”

Section: Discussionmentioning

confidence: 60%

Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

et al. 2012

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BACKGROUND/OBJECTIVES:Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors. RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P diff o0.01). None of the polymorphisms was associated with risk of CRC or cancers of the colon or rectum. Heavy alcohol intake was more strongly associated with CRC risk among carriers of the rs1573496(C) allele, with odds ratio equal to 2.13 (95% confidence interval: 1.26-3.59) compared with wild-type subjects with low alcohol consumption (P interaction ¼ 0.07). CONCLUSIONS: The rs1229984(A) (ADH1B) allele was associated with a reduction in alcohol consumption. The rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms were not associated with CRC risk overall in Western-European populations. However, the relationship between alcohol and CRC risk might be modulated by the rs1573496 (ADH7) polymorphism.

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Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case–control study

Cited by 23 publications

References 17 publications

Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

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