Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan

Fukushima, Wakaba; Miyake, Yoshihiro; Tanaka, Keiko; Sasaki, Satoshi; Kiyohara, Chikako; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Miki, Takami; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki

doi:10.1186/1471-2377-10-111

Cited by 24 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 unmatched case‐control studies performed in China and Japan. 1 study did not find an association between total alcohol consumption and PD risk but found that sake consumption was associated with increased PD risk, another study found that frequent consumption of hard liquor was associated with decreased PD risk …”

Section: Analytical Epidemiologymentioning

confidence: 94%

“…One case‐control study from Japan did not find a significant association between total alcohol consumption and PD risk . However, among the different types of alcohol, only Japanese sake (rice wine) was significantly associated with increased PD risk (adjusted or of ≥66 g ethanol per day; 3.39, 95% CI: 1.10–11.00) …”

Section: Analytical Epidemiologymentioning

confidence: 99%

“…The prospective cohort study from Singapore found a non‐significant decreased risk (RR 0.6, 95% CI: 0.31–1.16) in “at least weekly drinkers” compared to “none,” or “less than weekly” drinkers . One case‐control study from Japan did not find a significant association between total alcohol consumption and PD risk . However, among the different types of alcohol, only Japanese sake (rice wine) was significantly associated with increased PD risk (adjusted or of ≥66 g ethanol per day; 3.39, 95% CI: 1.10–11.00) …”

Section: Analytical Epidemiologymentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of Parkinson's Disease—East Versus West

Abbas

Tan

2017

Movement Disord Clin Pract

132

View full text Add to dashboard Cite

Background: The cause of PD at present remains unknown. A number of epidemiological studies have been conducted across the globe to ascertain the disease burden and the possible risk factors. In this review, we analyze the various studies from East and West with an aim to observe the important similarities and differences in the disease occurrence and risk factor profile. Methods: A comprehensive search of descriptive and analytical epidemiological studies was undertaken. The descriptive studies and meta-analysis providing the standardised population rates were selected. The demographics, ethnicity and geographical differences between East and West were analysed. In analytical epidemiology, more established and well-studied non-genetic risk factors for PD were reviewed utilising the prospective cohort studies, case control studies and meta-analysis where available. Results and Conclusion: PD is more common with increasing age and shows male predominance, which is more obvious in Western studies. The PD prevalence and incidence rates are slightly lower in the East compared to the West. Incidence studies on different ethnic populations in the same country have also found a lower occurrence of PD amongst Easterners compared to Westerners. Setting methodological differences aside, studies from East and West suggest a role for both environmental and genetic risk factors in PD causation. Smoking, caffeine intake and pesticide exposure are well-established risk factors across regions. There is a robust data for dairy product consumption, urate levels and physical activity in the West while studies on certain risk factors like head injury and alcohol show conflicting and mixed results.Parkinson's disease (PD) is the second most common neurodegenerative disorder and in the majority of cases, its cause remains unknown. Epidemiology refers to the study of distribution and determinants of health related events and their application in the control of diseases. 1In descriptive epidemiology, time, place, and person define the health events; while analytical epidemiology helps to identify and quantify the relationship between exposure and a particular health outcome. 1The epidemiological studies determining race and ethnicity help us to understand the roles of, and interaction between, genetic and environmental factors in disease causation. 2In the present review, we analyze the epidemiological features of PD patients between Western and Eastern countries. The division of East and West is not clear, as the definition varies depending on whether historical, geographical, economic, cultural, or political factors are considered. In this review, we have adopted the cultural definition that considers Asia, and the Middle East as "Eastern" countries; Russia, Europe, the Americas, Australia, and New Zealand as "Western" countries. West studies. In addition, the results of relevant meta-analysis were also discussed.There are a number of PD descriptive epidemiology studies in the literature. The comparison of these studies rem...

show abstract

Section: Analytical Epidemiologymentioning

confidence: 94%

Section: Analytical Epidemiologymentioning

confidence: 99%

Section: Analytical Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of Parkinson's Disease—East Versus West

Abbas

Tan

2017

Movement Disord Clin Pract

132

View full text Add to dashboard Cite

show abstract

“…Alcohol intake might influence PD risk by the addictive behavior itself and the serum uric acid–elevating effect of beer, because serum uric acid is inversely associated with PD risk and could delay PD progression . However, results from the observational studies on alcohol intake and PD risk are not consistent, and both positive and negative results have been reported. In addition, the dose‐response relationship is still unclear.…”

mentioning

confidence: 99%

Alcohol intake and risk of Parkinson's disease: A meta‐analysis of observational studies

2014

View full text Add to dashboard Cite

show abstract

“…Several epidemiological studies have investigated the association between alcohol intake and the risk of Parkinson's disease (PD) . Results from some studies suggest a modestly lower PD risk with increasing alcohol intake whereas others did not find a protective effect . In addition, investigators of the NIH‐AARP Diet and Health Study reported that low beer consumption was associated with lower PD risk compared to nonbeer drinkers whereas greater liquor consumption was associated with a higher risk, suggesting that the effect of alcohol on PD risk may depend on specific types of alcoholic beverages …”

mentioning

confidence: 99%

Alcohol Intake and Parkinson's Disease Risk in the Million Women Study

et al. 2019

View full text Add to dashboard Cite

BACKGROUND Alcohol intake may be associated with a lower risk of Parkinson's disease (PD), but findings from previous studies have been inconclusive. OBJECTIVE To determine the association between alcohol intake and PD risk in the Million Women Study, a large, prospective study of women in the UK. METHODS Between 1996 and 2001, approximately 1.3 million women in the UK, mean age 56 (standard deviation, 5) years, were recruited into the Million Women Study. Information on alcohol intake, lifestyle factors, and medical history was collected at recruitment by questionnaire. Information on incident cases of PD was ascertained by record linkage to national hospital admission records and death registrations. We estimated multivariable‐adjusted relative risks and corresponding 95% confidence intervals using Cox proportional hazards models according to categories of alcohol intake. RESULTS During an average of 17.9 years of follow‐up, 11,009 women had a new record of PD among 1,309,267 women. In drinkers, the multivariable‐adjusted relative risk comparing women who drank more than 14 drinks of alcohol per week with women who drank 1 to 2 drinks of alcohol per week was 0.99 (95% confidence interval: 0.90, 1.10). Results did not materially change after excluding the first 10 years of follow‐up (relative riskadjusted = 1.01; 95% confidence interval: 0.90, 1.13). There were no significant trends in alcohol‐related PD risk among never smokers. Additionally, examining this association by type of alcohol intake also yielded null findings. CONCLUSION These results do not support an association between alcohol intake and PD risk in women. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

show abstract

Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan

Cited by 24 publications

References 31 publications

Epidemiology of Parkinson's Disease—East Versus West

Epidemiology of Parkinson's Disease—East Versus West

Alcohol intake and risk of Parkinson's disease: A meta‐analysis of observational studies

Alcohol Intake and Parkinson's Disease Risk in the Million Women Study

Contact Info

Product

Resources

About