Alcohol-Induced Liver Disease

Hübscher, Stefan G.

doi:10.1016/b978-0-443-06803-4.00030-7

Cited by 2 publications

(1 citation statement)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Targeted antioxidants, like mitochondria-targeted ubiquinone, may reduce the damage to the liver caused by drinking too much alcohol and lead to better therapeutic effects. 4 The plant Acmella oleracea (L.) R. K. Jansen, https://doi.org/10.18231/j.ijmr.2023.008 2394-546X/© 2023 Innovative Publication, All rights reserved. 43 sometimes referred to as Spilanthes acmella var.…”

Section: Introductionmentioning

confidence: 99%

In vitro pharmacological activities of methanol extract of Acmella oleracea leaves: A variety grown in Dhaka, Bangladesh

Alam

Akash²

2023

IJMR

View full text Add to dashboard Cite

is known as toothache plant belongs to the family of Asteraceae. It is treated as a medicinal remedy like tuberculosis, illness, cough, rheumatism, and illness. This study was concentrated on the antioxidant, cytotoxic, antimicrobial & thrombolytic activities of methanol extract of leaves using in vitro model. The antioxidant activity was estimated as trolox equivalent antioxidant capacity utilizing the DPPH and reducing power tests. The plant extract was tested for its cytotoxic action using a brine shrimp lethality bioassay, thrombolytic activity using clot disruption, and antibacterial activity using a disc diffusion assay technique against four distinct gram-positive also gram-negative bacteria. ICvalue of standard ascorbic acid for DPPH was 7.8µg/ml and the IC50 of the methanol extract of leaves was 198.34µg/ml that was moderate effect at all compare with ascorbic acid. Thrombolytic assay of Streptokinase as a positive control showed 88.49% where the extract shows 18.69% lytic activity shows the assay. In this study, the sample of LC results of cytotoxicity assay was 1.431 µg/mL which can be treated as less activity. Moreover, the extracts showed low to moderate antibacterial activity against both gram-negative and gram-positive bacterial stains (zone of inhibition-10-26 mm). Vibrio Mimicus bacteria stains exhibited the highest level of activity, with a range of 23 for the diameter of the growth inhibition zone. The current review shows leaf extracts of may be used as a source of antioxidant and thrombolytic activity, as well as a significant source of antibacterial and anticancer substances. Further research is required to evaluate in-vivo the pharmacological activity of leaves in order to identify the essential metabolites and potential mechanisms.

show abstract

Section: Introductionmentioning

confidence: 99%