Alcohol induced testicular damage: Can abstinence equal recovery?

Dosumu, Olufunke O.; Osinubi, AA; Duru, Francis Ikechukwu

doi:10.1016/j.mefs.2014.01.003

Cited by 34 publications

(45 citation statements)

References 50 publications

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“…In the present study, histopathological results and stereological measurements showed extensive degeneration of spermatogenic cells with thinning and disruption of the basement membrane in ethanol alone as well as it cotreatment groups C and D. Decreased volume density and absolute volume of germinal epithelium, widened lumen with widened hypocellular interstitium were also observed in these groups. This may be due to the morphological alterations of the mitochondria which contributes to apoptosis and necrotic cell death resulting in degradation of the germinal epithelium and interstitial cells (Dosumu et al ., ). The consequence of prolonged toxic xenobiotics on actively dividing cells during spermatogenetic cell division ultimately resulting in cessation may also play a significant role in germinal cell degeneration (Vidal & Whitney, ).…”

Section: Discussionmentioning

confidence: 97%

“…The consequence of prolonged toxic xenobiotics on actively dividing cells during spermatogenetic cell division ultimately resulting in cessation may also play a significant role in germinal cell degeneration (Vidal & Whitney, ). Our result agrees with previous studies which reported that the induction of HAART (Azu et al ., ; Ogedengbe et al ., ) or alcohol (Dosumu et al ., ; Akang et al ., ) causes severe effects on germinal cells leading to extensive necrosis and disruption of spermatogenensis. Decreased seminiferous tubular diameter, widened lumen, and hypocellular interstitium were also observed.…”

Section: Discussionmentioning

confidence: 98%

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Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

et al. 2018

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The consumption of alcohol by people living with HIV/AIDS is associated with a graver prognosis. Long-term use of antiretrovirals may have certain health challenges that may be aggravated by concomitant alcohol use. This study investigated virgin coconut oil (VCO) as an adjuvant to the deleterious effects of highly active antiretroviral therapy (HAART) and alcohol on the cyto-architecture and functioning of the testis. Forty adult male Sprague-Dawley rats, weighing 165~176 g, were divided into eight groups and treated according to protocol. Testicular histology, stereological parameters, seminal fluid, testosterone, luteinizing hormone, follicle-stimulating hormone, the antioxidants marker malondialdehyde (MDA), and antioxidant glutathione (GSH) were examined. The use of ethanol alone and ethanol + HAART showed extensive degeneration in the seminiferous epithelium, decreased semen quality, disorganized basement membrane and widened, hypocellular interstitium. GSH was significantly decreased in the ethanol alone treated group with no significant effect on testosterone, LH, and MDA levels. Adjuvant treatment with VCO at low dose (2.5 mL/kg/bw) improved sperm motility with a partial restoration of the histopathological alterations. High doses of VCO (5.0 mL/kg/bw) showed greater improvement with respect to sperm counts, increased FSH hormonal and GSH antioxidant levels, and a well-preserved testicular cyto-architecture.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

et al. 2018

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“…Although T. conophorum seed had been shown to improve spermatogenesis in animals by increasing sperm motility, sperm viability, sperm count, testosterone, estradiol, LH and FSH levels (Enujiugha, ; Ikpemel et al., ), while ethanol has been implicated in induction of testicular dysfunction and impairment of spermatogenesis in animals and humans (Dosumu et al., , ; Emanuele & Emanuele, ; Little et al., ; Maneech et al., ; Martinez et al., ; Salonen et al., ; Yen & Jaffe, ). This study focuses on the effect of the extract of T. conophorum leaves on fertility biomolecules in male rats with chronic consumption of ethanol.…”

Section: Discussionmentioning

confidence: 99%

“…Alcohol abuse had been considered as one of the problems associated with poor semen production and sperm quality (Abel, ; Talabi, Sarchesmeh, Khalili, & Tabibreyad, ). Reports have shown that chronic and acute consumption of alcohol cause fertility disturbances which include low sperm count and motility, reduced serum/plasma testosterone level, testicular atrophy, irregularity in the diameter of the seminiferous tubules, sexual dysfunction and impaired sperm production in both humans and animals (Dosumu, Duru, Osinubi, Oremosu, & Noronha, ; Dosumu, Osinubi, & Duru, ; Emanuele & Emanuele, ; Little, Adams, & Cicero, ; Maneech et al., ; Martinez et al., ; Salonen, Pakarinen, & Huhtaniemi, ; Yen & Jaffe, ).…”

Section: Introductionmentioning

confidence: 99%

Ethanol-induced male infertility: Effects of aqueous leaf extract ofTetracarpidium conophorum

et al. 2017

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This study investigated the effects of Tetracarpidium conophorum leaf extract on infertility induced by ethanol in male rats. Thirty rats were randomly divided into six groups of five animals each: Group 1 (positive control) received 0.9% saline only; Group 2 (ethanol alone) were given only 30% ethanol orally at 7 ml/kg body weight per day, thrice in a week; groups 3, 4 and 5 were given ethanol and co-treated with 50, 500 and 1,000 mg/kg body weight of leaf extract, respectively, while Group 6 was given ethanol and co-treated with a fertility drug, clomiphene citrate. Ethanol treatment resulted in significant (p < .05) decrease in LDH activity, G-6PDH activity, glycogen content, 3β and 17β HSD activities and testicular and epididymal Zn and Se contents and furthermore decrease in testicular sperm count, viability and marked increment in total sperm abnormalities, rate of sperm analysis parameters and consequently decreased reproductive hormone levels. Interestingly, co-administration of ethanol with either T. conophorum extract or drug almost ameliorated the toxic assault imposed by ethanol on reproductive organs and improved seminal qualities of the rats.

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“…Assessment of hormonal profile showed a significant decrease in testosterone level while LH and FSH remained unchanged. Recovery from these changes was observed as the testosterone level increased especifically on the seminiferous epithelium [30] (Figure 7). Dosumu previously reported that ethanol changes the structure of the mitochondria of the testicular cells with subsequent compromise in testicular energy metabolism [31].…”

Section: Alcohol-induced Liver Fibrosismentioning

confidence: 96%

Effect of liver fibrotic changes on testicular histological structure: An updated review

Faddladdeen¹

2019

Ann Clin Anal Med

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The liver plays a crucial role in maintaining adequate endocrine homeostasis including the endocrine function of the testis. Testicular atrophy and gonadal dysfunction have been clinically reported in advanced cirrhotic liver diseases. This study was conducted to review the effect of liver fibrotic changes induced by different agents on the structure of testis and the mechanisms underlying these effects. Chemical-induced liver fibrosis was found to have a negative impact on testicular structures. Carbon tetrachloride (CCl4) was frequently described to increase apoptosis of spermatogenic cells and reduced testicular transferrin expression through enhancing lipid peroxidation or direct toxic effect on the testis. Thioacetamide, another hepatotoxin, was reported to have harmful effects on sperm structure and function. Deltamethrin had hepatic changes that were associated with marked degeneration in rat seminiferous tubules. Cyclosporine A, an immunosuppressive drug, induced Sertoli and germ cell vacuolation besides inducing hepatic cytotoxicity. Testes of rats which chronically received alcohol, showed hypocellularity of the seminiferous tubules, degeneration of germinal epithelial and interstitial cells along with reduced sperm count and motility which was attributed to changes in the structure of the mitochondria. Portasystemic shunting and portal hypertension in rats were associated with reduced volume of germinal epithelium, reduced cell birth, reduced or complete loss of spermatogenic activity and marked increase in apoptosis. Virus-induced chronic active hepatitis was associated with sperm damage and reduced sperm quality parameters. Conclusion: Hepatic fibrotic changes induced by different injurious stimuli were found to have a harmful impact on testicular structure and function.

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Alcohol induced testicular damage: Can abstinence equal recovery?

Cited by 34 publications

References 50 publications

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

Ethanol-induced male infertility: Effects of aqueous leaf extract ofTetracarpidium conophorum

Effect of liver fibrotic changes on testicular histological structure: An updated review

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