Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats

Zhu, Shimin; Chen, Pingping; Chen, Mingzhu; Ruan, Jiawei; Ren, Wanying; Zhang, Xinyu; Gao, Yang; Li, Yanqin

doi:10.1007/s00213-019-05433-7

Cited by 1 publication

(3 citation statements)

References 49 publications

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“…Consistent with this work, intermittent alcohol exposure has not been shown to affect cocaine self-administration (Aspen and Winger, 1997;Fredriksson et al, 2017) or the reinforcing properties of cocaine measured via demand curves in rhesus monkeys (Winger et al, 2007). In addition, intermittent alcohol exposure has not been shown to affect progressive ratio tests of motivation for cocaine (Mateos-García et al, 2015), or the long-term reconsolidation of preference for cocaine in drug-paired contexts (Zhu et al, 2020) in rats. In contrast, adolescent alcohol exposure has been shown to have long-lasting effects on cocaine self-administration and reward, suggesting that this population is particularly susceptible to the effects of polysubstance use.…”

Section: Psychostimulantssupporting

confidence: 69%

“…Similar to psychostimulant polydrug studies, sequential use of heroin and cocaine has not been found to alter heroin selfadministration or reinstatement of heroin-seeking (Crummy et al, 2020). Although alcohol pretreatment can prevent the long-term reconsolidation of preference for morphine in drugpaired contexts (Zhu et al, 2020), adolescent alcohol exposure enhances the development of a morphine CPP (Molet et al, 2013). This finding indicates that the long-term effects of adolescent alcohol exposure are generalizable to multiple drug classes.…”

Section: Opioidsmentioning

confidence: 73%

“…More recently, studies are comparing single versus polysubstance self-administration to determine the effect of drug history on drug-induced molecular and circuit alterations (Briggs et al, 2018;Stennett et al, 2020;Zhu et al, 2020). Additionally, paradigms based on behavioral economic principles can determine the preferred level of drug intake (i.e.…”

Section: Behavioral Models Of Addiction In Polydrug Studiesmentioning

confidence: 99%

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One Is Not Enough: Understanding and Modeling Polysubstance Use

et al. 2020

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Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative affect, and motivation to maintain drug consumption. SUDs are highly prevalent, with 35 million people meeting criteria for SUD. While drug use and addiction are highly studied, most investigations of SUDs examine drug use in isolation, rather than in the more prevalent context of comorbid substance histories. Indeed, 11.3% of individuals diagnosed with a SUD have concurrent alcohol and illicit drug use disorders. Furthermore, having a SUD with one substance increases susceptibility to developing dependence on additional substances. For example, the increased risk of developing heroin dependence is twofold for alcohol misusers, threefold for cannabis users, 15fold for cocaine users, and 40-fold for prescription misusers. Given the prevalence and risk associated with polysubstance use and current public health crises, examining these disorders through the lens of co-use is essential for translatability and improved treatment efficacy. The escalating economic and social costs and continued rise in drug use has spurred interest in developing preclinical models that effectively model this phenomenon. Here, we review the current state of the field in understanding the behavioral and neural circuitry in the context of co-use with common pairings of alcohol, nicotine, cannabis, and other addictive substances. Moreover, we outline key considerations when developing polysubstance models, including challenges to developing preclinical models to provide insights and improve treatment outcomes.

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