Alcohol intake and quantitative MRI findings among community dwelling Japanese subjects

Fukuda, Kenji; Yuzuriha, Takefumi; Kinukawa, Naoko; Ryo, Murakawa; Takashima, Yuki; Uchino, Akira; Ibayashi, Setsuro; Iida, Mitsuo; Yao, Hiroshi; Hirano, Minoru

doi:10.1016/j.jns.2008.11.007

Cited by 22 publications

(24 citation statements)

References 39 publications

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“…Alcohol intake has been found to be a cause of brain atrophy in many studies [17][18][19][20][21][22] ; however, in our young subjects, alcohol intake did not infl uence the brain-to-skull ratio. A recent report by Lee et al demonstrated that brain metabolites are altered in young alcoholics, but no difference was found in volumetric variables between alcoholics and controls.…”

Section: Discussioncontrasting

confidence: 74%

Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study

Adachi¹,

Shibata²,

Sato³

et al. 2011

Jpn J Radiol

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Section: Discussioncontrasting

confidence: 74%

Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study

Adachi¹,

Shibata²,

Sato³

et al. 2011

Jpn J Radiol

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“…Our earlier study as well as this study revealed that even a low amount of regular drinking may be a risk factor for SBI in community-dwelling Japanese people. 13 Effects of alcohol on SBI were evident also in the selected group of female subjects with natural menopause aged 60 years or older (Table 3). Discrepancies between the results of our study and those of the earlier studies may be partly explained by racial differences such as obviously lower body mass index of Japanese compared with those of western populations, and the frequent genetic deficiency in alcohol detoxification in Japanese and Orientals.…”

Section: Sex Differences In Silent Brain Infarction Y Takashima Et Almentioning

confidence: 85%

“…Vascular risk factors were defined as described earlier. 12,13 Briefly, arterial hypertension was considered present if a subject had a history of repeated blood pressure recordings above 140/90 mm Hg or the subject was being treated for hypertension. Diabetes mellitus was defined as fasting plasma glucose 47.77 mmol l -1 and/or HbA1c 46.0%, or an earlier diagnosis of diabetes mellitus.…”

Section: Methodsmentioning

confidence: 99%

“…We obtained information about usual alcohol intake and type of alcohol consumed from a detailed questionnaire as described earlier. 13 We defined one drink as 10 g of ethanol, calculated as follows: 350 ml beers as 1.4 drinks, 180 ml sake (rice wine) as 2.2 drinks, 180 ml shochu (white spirits) as 3.6 drinks, 60 ml whisky as 2.0 drinks and 120 ml wine as 1.2 drinks. In this study, we defined alcohol intake as one drink or more per week, because the earlier study from the same population revealed that even light drinkers had the similar risk for SBI (odds ratio (OR)¼4.1, 95% confidence interval (CI)¼1.7-10.0) as moderate drinkers (OR¼3.1, 95% CI¼1.3-7.0).…”

Section: Methodsmentioning

confidence: 99%

“…SBI was shown as low signal intensities on T1-weighted images, and their size was 5 mm or larger as described earlier ( Figure 1). 12,13 We differentiated enlarged perivascular spaces from SBI on the basis of their location, shape and size. 15,16 The WMLs were defined as isointense with normal brain parenchyma on T1-weighted images, high signal intensity areas on T2-weighted images and were classified into deep white matter lesions (DWMLs) and periventricular hyperintensities (PVHs).…”

Section: Methodsmentioning

confidence: 99%

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Sex differences in the risk profile and male predominance in silent brain infarction in community-dwelling elderly subjects: the Sefuri brain MRI study

et al. 2010

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Although brain infarction is more common in men, the male predominance of silent brain infarction (SBI) was inconsistent in the earlier studies. This study was to examine the relationship between sex differences in the risk profile and SBI. We conducted a population-based, cross-sectional analysis of cardiovascular risk factors and SBI on MRI. We asked all the female participants about the age at natural menopause and parity. SBI was detected in 77 (11.3%) of 680 participants (266 men and 414 women) with a mean age of 64.5 (range 40-93) years. In the logistic analysis, age (odds ratio (OR)¼2.760/10 years, 95% confidence interval (CI)¼2.037-3.738), hypertension (OR¼3.465, 95% CI¼1.991-6.031), alcohol intake (OR¼2.494, 95% CI¼1.392-4.466) and smoking (OR¼2.302, 95% CI¼1.161-4.565) were significant factors concerning SBI. Although SBI was more prevalent among men, this sex difference disappeared on the multivariate model after adjustment for other confounders. In 215 women aged 60 years or older, age at natural menopause, early menopause, duration of menopause, number of children and age at the last parity were not significantly associated with SBI after adjustment for age. Hypertension and age were considered to be the major risk factors for SBI in community-dwelling people. Male predominance in SBI was largely due to higher prevalence of alcohol habit and smoking in men than in women in our population.

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Omic analyses unravels global molecular changes in the brain and liver of a rat model for chronic Sake (Japanese alcoholic beverage) intake

et al. 2009

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The effects of chronic administration of Sake (Japanese alcoholic beverage, Nihonshu) on brain and liver of female F334 (Fisher) rats were surveyed via global omic analyses using DNA microarray, 2-DE, and proton nuclear magnetic resonance. Rats weaned at 4 wk of age were given free access to Sake (15% alcohol), instead of water. At 13 months of age, and 24 h after withdrawal of Sake supply, rats were sacrificed, and the whole brain and liver tissues dissected for analyses. In general, molecular changes in brain were found to be less than those in liver. Transcriptomics data revealed 36 and 9, and 80 and 62 up- and down-regulated genes, in the brain and liver, respectively, with binding and catalytic activity gene categories the most prominently changed. Results suggested Sake-induced fragility of brain and liver toxicity/damage, though no significant abnormalities in growth were seen. At protein level, a striking decrease was found in the expression of NADH dehydrogenase (ubiquinone) Fe-S protein 1 in brain, suggesting attenuation of mitochondrial metabolism. In liver, results again suggested an attenuation of mitochondrial function and, in addition, glycoproteins with unknown function were induced at protein and gene levels, suggesting possible changes in glycoprotein binding in that organ. Metabolomic analysis of brain revealed significant increases in valine, arginine/ornithine, alanine, glutamine, and choline with decreases in isoleucine, N-acetyl aspartate, taurine, glutamate, and gamma aminobutyric acid. Our results provide a detailed inventory of molecular components of both brain and liver after Sake intake, and may help to better understand effects of chronic Sake drinking.

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Alcohol intake and quantitative MRI findings among community dwelling Japanese subjects

Cited by 22 publications

References 39 publications

Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study

Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study

Sex differences in the risk profile and male predominance in silent brain infarction in community-dwelling elderly subjects: the Sefuri brain MRI study

Omic analyses unravels global molecular changes in the brain and liver of a rat model for chronic Sake (Japanese alcoholic beverage) intake

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