Alcohol Intake Measured by Phosphatidylethanol in Blood and the Lifetime Drinking History Interview Are Correlated with the Extent of Psoriasis

Abstract

Background: Psoriasis has been reported to be associated with alcohol consumption. Objective: To investigate the level of alcohol intake in individuals with psoriasis and correlate intake with the extent of disease and pruritus. Methods: Twenty-nine outpatients (15 females and 14 males) with stable chronic plaque psoriasis of moderate severity were recruited. The Psoriasis Area and Severity Index (PASI) and the degree of pruritus (visual analogue scale) were compared with measures of drinking habits as determined by the Lifetime Drinking History (LDH), the Alcohol Use Disorders Identification Test and whole-blood phosphatidylethanol (PEth), an alcohol-specific biomarker. Results: The majority of patients were social drinkers with moderate alcohol consumption as determined by PEth and LDH. Alcohol consumption correlated significantly with the PASI score. There was no correlation between alcohol use and pruritus. Conclusion: The level of alcohol consumption is correlated with the extent of psoriasis.

Risk of Myocardial Infarction in Patients with Psoriasis and Psoriatic Arthritis: A Nationwide Cohort Study

“…Indeed, inflammation is important in atherogenesis and atherosclerosis (29,30), and systemic inflammation has been put forward as a potential explanation for the observed increased prevalence and risk of CVD in patients with psoriasis. However, patients with psoriasis also tend to exercise less (31) and smoke more than the general population (32), and the level of alcohol consumption is correlated with the extent of psoriasis (33). In addition, presence of depression also appears to significantly affect the CVD risk in patients with psoriasis (34).…”

Defining the Natural Course of Psoriasis: A Single-Center Cohort Study of 100 Patients

“…Although there was no statistically significant difference between smokers and non-smokers (p=0.894), alcohol user and not user (p=0.749) in terms of disease activity in the last year in this study, there are many studies that support smoking is an independent risk factor for the development of psoriasis (11,12) and there are some studies that demonstrate the relationship between smoking and clinical severity of psoriasis (13)(14)(15). In terms of alcohol use and psoriasis severity, there are contradictory results in the literature (15,16). Although, the marital status was the only statistically significant one, the duration between the occurrence of the first symptom and the diagnosis of psoriasis was shorter in women than men and in patients with no alcohol intake than alcohol user.…”

Genetic factors are stressed variably by onset age‐based sample selection in psoriasis: A hint from major histocompatibility complex region‐based analysis

“…Environment hazards such as smoking and alcohol consumption were shown to independently increase the risk of LOP. 29,30 Therefore, this provided a clue that younger individuals might exhibit more genetic risks with effects on psoriasis pathogenesis compared to elder individuals. In the present study, we did not recognize smoking and alcohol consumption as confounders because the quantitative parameters were hardly available and other hazards, such as life style, might also have influenced the onset of psoriasis.…”