Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens

Alaux‐Cantin, Stéphanie; Warnault, Vincent; Legastelois, Rémi; Botia, Béatrice; Pierrefiche, Olivier; Vilpoux, Catherine; Naassila, Mickaël

doi:10.1016/j.neuropharm.2012.12.007

Cited by 155 publications

(170 citation statements)

References 56 publications

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“…In rats, high-dose ethanol exposure increases both ethanol self-administration and ethanol preference (Camarini & Hodge, 2004;Crabbe et al, 2012;Griffi n et al, 2009;O'Dell et al, 2004;Rimondini et al, 2002Rimondini et al, , 2003Timberlake et al, 2009), even when evidence of tolerance is absent (Alaux-Cantin et al, 2013;Cox et al, 2013;Stuber et al, 2008). We have established that rats reliably consume enough ethanol in a gelatin vehicle within an hour to result in brain ethanol levels of 8-10 mM (Li et al, 2010;Peris et al, 2006;Rowland et al, 2005), which is remarkably similar to that achieved after one to two alcoholic beverages over the same period in humans (Brick 2006).…”

supporting

confidence: 63%

Intermittent High-Dose Ethanol Exposure Increases Ethanol Preference in Rats

Peris¹,

Rhodes²,

McCullough³

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Alcohol use disorders have both high social and economic costs and are among the leading causes of preventable death in the United States. Understanding the factors that contribute to escalation of alcohol intake is important in developing effective treatments for this problem. This study further characterizes the effects of limited intermittent exposure to high levels of alcohol on the preference for alcohol consumption over other incentives. Method: Fourteen male, Sprague-Dawley rats were trained to consume ethanol in a gelatin vehicle. They were then given free access to both ethanol gelatin and plain gelatin during daily choice periods interspersed with nonchoice periods (only plain gelatin access). After baseline ethanol preference was established, half of the rats were given eight injections of 3 g/kg ethanol during nonchoice periods (spread out over about 2 months), and the other half received saline injections. Ethanol preference was measured during subsequent choice periods. Results: Intermittent ethanol injections increased ethanol preference from 21% (SEM = 2.3%) of their total gelatin consumption during the fi rst choice period to 46.8% (SEM = 3.4%) during the third choice period. The saline-treated rats had no signifi cant change in ethanol preference. In addition, the ethanoltreated rats exhibited higher ethanol intake than saline-treated rats when ethanol gelatin was the only choice available. Conclusions: The results indicate that intermittent exposure to sedative doses of ethanol leads to an increased ethanol preference in rats. This suggests that occasional high-dose alcohol exposure could be an important contributor to the development of enhanced ethanol intake, which may affect the incidence of chronic alcoholism. (J. Stud. Alcohol Drugs, 76, 165-173, 2015)

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supporting

confidence: 63%

Intermittent High-Dose Ethanol Exposure Increases Ethanol Preference in Rats

Peris¹,

Rhodes²,

McCullough³

et al. 2015

J. Stud. Alcohol Drugs

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“…In general, the possible influence of all these factors on alcohol consumption in males and females, in situations of no previous experience with the substance as well as in situations with the previous experience, warrants further and more detailed study. In addition, some animal studies seem to indicate that pre-exposure to alcohol may constitute a major vulnerability factor in the development of alcoholism (Alaux-Cantin et al, 2013). However there is little research to date on the mechanisms underlying this susceptibility, including the possible influence of sex, which is why we address this issue in our second experiment.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Torre

Escarabajal

Zapata

2015

Pharmacology Biochemistry and Behavior

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“…Alcohol, similar to virtually all abused substances, increases dopamine transmission within the ventral striatum (Cheer et al, 2007;Di Chiara and Imperato 1986;. Importantly, the mesolimbic dopamine system continues to mature during the adolescent period (Chambers et al, 2003), suggesting that adolescent alcohol use may alter its function, resulting in abnormal reward-related learning processes that impact decision making (Alaux-Cantin et al, 2013;Casey and Jones 2010;Goudriaan et al, 2007;Johnson et al, 2008;McClory and Spear 2014;Nasrallah et al, 2011;Philpot et al, 2009;Toalston et al, 2014;Zeigler et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Spoelder

Tsutsui

Lesscher

et al. 2015

Neuropsychopharmacol

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Adolescent alcohol use remains a major public health concern due in part to well-established findings implicating the age of onset in alcohol use in the development of alcohol use disorders and persistent decision-making deficits in adults. We have previously demonstrated that moderate adolescent alcohol consumption in rats promotes suboptimal decision making and an associated perturbation in mesolimbic dopamine transmission in adulthood. Dopamine-dependent incentive learning processes are an integral component of value-based decision making and a fundamental element to many theoretical accounts of addiction. Thus we tested the hypothesis that adolescent alcohol use selectively alters incentive learning processes through perturbation of mesolimbic dopamine systems. To assess incentive learning, behavioral and neurochemical measurements were made during the acquisition, maintenance, extinction, and reacquisition of a Pavlovian conditioned approach procedure in adult rats with a history of adolescent alcohol consumption. We show that moderate adolescent alcohol consumption potentiates stimulus-evoked phasic dopamine transmission, measured in vivo by fast-scan cyclic voltammetry, in adulthood and biases individuals toward a dopamine-dependent incentive learning strategy. Moreover, we demonstrate that animals exposed to alcohol in adolescence are more sensitive to an unexpected variation in reward outcomes. This pattern of phasic dopamine signaling and the associated bias in learning may provide a mechanism for the well-documented vulnerability of individuals with early-life alcohol use for alcohol use disorders in adulthood.

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Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens

Cited by 155 publications

References 56 publications

Intermittent High-Dose Ethanol Exposure Increases Ethanol Preference in Rats

Intermittent High-Dose Ethanol Exposure Increases Ethanol Preference in Rats

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

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