V~tnam combat veterans suffering h m post-tmwnatic stress &o&r (PTSD) who had requested treatment through a spcial VA-sponsored PTSD treatment program were evaluated wing the Diagnostic Interview Schedule (DIS). Based on the DIS, 91.12% of the sample had a l i f t h e &gnosis of substance abuse or dependence and thk was, by fw, the most fiquent co-diagnosk in the sample.The most common reason for patients not completing the treatment program was for use of rUegal substances or alcohol while in the program, even though they were aware that to do so meant that they would be either &charged or t r a d e d to another unit. The percentage of other co-diagnoses, and an estimate of currentness for all Ax& I diagnoses were also pmented on the sampk of 102 patie&. It was detmined that for this popuhtion, the ymptoms of substance abwe wem chronic and were inedricably intertwined with PTSD sympoms and with the inihhl stressor (combat). Treatment p m m implications were discussed