Alcohol-nutrition interaction: 1984 update

Lieber, Charles S.

doi:10.1016/0741-8329(84)90072-7

Cited by 27 publications

(10 citation statements)

References 61 publications

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“…Most of the work to date on the interaction between nutrition and alcoholism has concerned deficiency states of micronutrients (17)(18)(19)(20). The main purpose of this study, however, was to investigate the relationship between dietary intake and alcohol consumption in a non-alcoholic population.…”

Section: Discussionmentioning

confidence: 98%

“…Data from studies of chronic alcohol abuse clearly show that alcohol can produce a secondary malnutrition due to deficient nutrient utilization (17). Most of the work to date on the interaction between nutrition and alcoholism has concerned deficiency states of micronutrients (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that consumption of alcoholic beverages may affect the metabolism of a number of nutrients (16)(17)(18)(19)(20). It is also known that chronic alcoholism is associated with several nutrient deficiencies, most notably vitamins B 12 , niacin, thiamine, zinc, and iron (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Implications for cancer epidemiology of differences in dietary intake associated with alcohol consumption

Hébert

Kabat

1991

Nutrition and Cancer

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Several dietary factors are thought to modify risk for cancers that are known to be associated with alcohol intake. In this study, we sought to identify and describe alcohol-related differences in dietary and nutritional factors that are potential independent predictors of cancer risk or effect modifiers or confounders of alcohol-cancer relationships. Data were obtained from a large hospital-based case-control study that was designed to estimate the cancer risk from various tobacco products. Study subjects consisted of 465 male and 300 female incident lung cancer cases and 870 male and 556 female hospitalized patient controls matched on age (+/- 5 yrs). Nutritional data were analyzed as log-transformed frequencies of 30 food items, 9 factor scores generated to describe overall patterns of dietary intake, and nutrient scores estimating daily intake of fat, vitamin A, fiber, and cholesterol. We observed many more significant differences in nutritional exposures by alcoholic beverage intake than would be expected merely by chance. For males, the most striking relationships included increased meat and egg consumption with increasing alcohol consumption and higher intake of cantaloupe and cold cereal among lighter drinkers. For females, we observed strong inverse relationships between alcohol consumption and reported intake of fruit, cold cereal, and ice cream. We also observed a direct association between alcohol and meat consumption, though it was weaker than that found among men. Findings based on factors and nutrients followed the pattern observed for the individual food items, with highest fat scores and lowest fruit scores among the heaviest drinkers. Implications for nutrient-alcohol interactions and statistical considerations are discussed.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Implications for cancer epidemiology of differences in dietary intake associated with alcohol consumption

Hébert

Kabat

1991

Nutrition and Cancer

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“…This has been ascribed to the toxic effect of ethanol on platelets and bone marrow [5,24]. In addition, intestinal malabsorption and impaired availability of nutrients in alcoholics [25] or several metabolic, hormonal, and toxic factors [1,6,40,41] might contribute to the impaired function of megakaryocytes or influence platelet function. Moreover, it is possible that platelets are made refractory by small amounts of ADP released from red cells during low-degree hemolysis in chronic alcoholics [23].…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol on platelet thromboxane formation after ethanol withdrawal in chronic alcoholics: An in vitro study

Neiman

1988

Res. Exp. Med.

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The effect of ethanol on the formation of platelet thromboxane B2 (TXB2), a stable metabolite of thromboxane A2 (TXA2) was studied in vitro in six chronic alcoholics, admitted for detoxification, and in six healthy volunteers. Immediately after cessation of heavy drinking platelet count and ADP-induced TXB2 formation were lower in alcoholics than in nonalcoholic volunteers (P less than 0.05). Ten days after withdrawal of ethanol platelet count increased, and skin bleeding time shortened (P less than 0.05). Ethanol had no effect on arachidonate-induced platelet TXB2 formation, whereas ethanol added to platelet suspension prior to stimulation by ADP resulted in a concentration-related inhibitory tendency in both alcoholics and nonalcoholic control subjects. This effect of ethanol may be of significance for primary hemostasis in alcoholics.

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“…Prevalence of undernutrition in alcoholics with alcoholic hepatitis due to both protein and caloric deficiency resulting from low ingestion and inadequate utilization of nutrients absorbed and in the present study we found serum albumin and total proteins level was significantly lower among the severe alcoholics. 29 The fact that the test for aminotransferases (AST) had high sensitivity demonstrates its capability for indicating liver damage in alcoholics; additionally, its high positive and negative predictive values allow the differentiation with high probability of individuals with and without liver disease. Whereas the results of our study which showed a positive correlation of AST levels among severe alcoholics is contradicting Rosman and Lieber where they state that activities of liver enzymes, including AST, have limited diagnostic usefulness in predicting the histologic staging.…”

Section: Discussionmentioning

confidence: 99%

Comparison of haematological parameters between alcoholics and non-alcoholics

Elanchezhian

Yoganandh

Mayilsamy³

et al. 2017

Int J Res Med Sci

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Background: Alcohol being one of the most commonly used drug, whose consequences include changes of CBC. The main causes leading to changes of CBC (complete blood count) are: myelosuppression that is accompanying with slight reduction in all blood cells, blood loss from gastrointestinal tract, malnutrition etc. Alcoholics may suffer from moderate anemia, characterized by enlarged, structurally abnormal RBC’s; mildly reduced numbers of WBC’s, especially of neutrophils; and moderately to severely reduced numbers of platelets. The objective of the study was to study the haematological manifestation among alcoholics based on the quantity and duration of alcohol intake and compare them with non-alcoholics.Methods: A cross-sectional study was conducted for a period of one year in our medical college hospital in medicine OPD with the collaboration of department of pathology and bio-chemistry. The study was started after getting the approval from the institutional ethical committee. A total of 150 study subjects were included in the study in which 50 were non-alcoholics, 50 were moderate alcoholics (less than or equal to two drinks per day for men and less than or equal to one drink per day for women) and the remaining 50 were severe alcoholics (more than 7 drinks a week in women and more than 14 drinks in a week in men). Blood investigations such as CBC, prothrombin time, liver function test, renal function test, folic acid levels and vitamin B12 levels were measured and the levels were compared between alcoholics and non-alcoholics.Results: Mean RBC count, mean MCH, MCHC were normal among the non-alcoholic group and it started decreasing among moderate alcoholics and more so with severe alcoholics and a similar type of result was also seen with total count and platelet count and the difference was found to be statistically significant. LFT, RFT, prothrombin time and vitamin B12 levels were found to be high and folate levels were decreased among alcoholics group when compared to non-alcoholics and the difference was statistically significant.Conclusions: Detection of hematological changes in chronic alcoholics and giving psychiatric counseling and treatment for alcohol dependence will decrease the future complications like cirrhosis liver, cardiac and renal disease, cerebellar degeneration, neuropathy, pancreatitis, etc. and reduce the morbidity and mortality in alcoholics.

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Alcohol-nutrition interaction: 1984 update

Cited by 27 publications

References 61 publications

Implications for cancer epidemiology of differences in dietary intake associated with alcohol consumption

Implications for cancer epidemiology of differences in dietary intake associated with alcohol consumption

Effects of ethanol on platelet thromboxane formation after ethanol withdrawal in chronic alcoholics: An in vitro study

Comparison of haematological parameters between alcoholics and non-alcoholics

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