Alcohol preference in mice lacking the Avpr1a vasopressin receptor

Sanbe, Atsushi; Takagi, Norio; Fujiwara, Yoko; Yamauchi, Junji; Endo, Toshiya; Mizutani, Reiko; Takeo, Satoshi; Tsujimoto, Gozoh; Tanoue, Akito

doi:10.1152/ajpregu.00708.2007

Cited by 24 publications

(24 citation statements)

References 55 publications

(92 reference statements)

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“…In the context of ethanol-induced CSP, OXT and AVP have contrasting effects: in male mice, these neuropeptides increase social behavior [1] and modify ethanol consumption [24–27]. Nonetheless, the lack of ethanol-induced CSP in KO Oxtr and KO Avpr1a females in the present study was consistent with our hypothesis.…”

Section: Discussionsupporting

confidence: 90%

“…OXT reduces ethanol consumption in wild-type (WT) rats [24] and mice [25]. Reports of ethanol consumption in mice lacking Avpr1a (KO Avpr1a ) are conflicting: one study of males and females found no effect [26], while another reported increased ethanol consumption and preference in males, with limited effects in KO Avpr1a females [27]. Because OXT and AVP enhance social behavior [28] but reduce drug [29, 30] and ethanol consumption [24, 25], we hypothesized that Oxtr and Avpr1a are necessary for conditioned effects of an ethanol-associated social stimulus.…”

Section: 1 Introductionmentioning

confidence: 99%

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Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice

Wood

Knoll

Levitt

2015

Physiology & Behavior

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Social behavior modulates response to alcohol. Because oxytocin (OXT) and vasopressin (AVP) contribute to rewarding social behavior, the present study utilized a genetic strategy to determine whether OXT and AVP receptors (OXTR, AVPR1a) are essential for female mice to demonstrate a conditioned social preference for ethanol. The study compared wild-type (WT) and knock-out (KO) females lacking either the Oxtr or Apr1a in a conditioned social preference (CSP) test. KO females and WT females from Het-Het crosses were pair-housed: KO, WT(ko). WT females from Het-WT crosses were pair-housed: WT(wt). Test mice received 2 g/kg ethanol or saline ip, and were paired four times each with one stimulus female (CS−) after saline, and with another female (CS+) following ethanol. After pairing, the time spent with CS+ and CS− females was measured. WT(wt) females showed conditioned preference for the CS+ female paired with ethanol, demonstrated by greater interaction time (p<0.05). In both KO lines, ethanol significantly reduced interaction with the CS+ female (p<0.05), and there was no change in interaction for WT(ko) females. Response to odors by habituation-dishabituation was unaffected in both KO lines, and the response to a hypnotic dose of ethanol also was the same as in WT mice. However, anxiety, measured as time on the open arms of the elevated plus maze, was reduced in KOOxtr females compared with WT(wt). The results suggest that Oxtr and Avpr1a are required for conditioned effects of an ethanol-associated social stimulus. The lack of CSP in WT(ko) females suggests that the quality of social interactions during postnatal and postweaning life may modulate development and expression of normal social responses.

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Section: Discussionsupporting

confidence: 90%

Section: 1 Introductionmentioning

confidence: 99%

Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice

Wood

Knoll

Levitt

2015

Physiology & Behavior

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“…One study found that V1aR-KO mice display increased ethanol consumption and preference (437), but another study found contradictory evidence (83). Also, one study and our unpublished study found that V1bR-KO mice do not show an increase in ethanol consumption and preference (83) (Tanoue et al, unpublished data).…”

Section: Water Intake Food Intake (Appetite) and Alcohol Intake (Prmentioning

confidence: 99%

“…It has been suggested that AVP inhibits the release of glutamate from the presynaptic terminal via the V1a receptor. Blockade of AVP/V1a receptor signaling results in elevation of glutamate levels in the CNS, which accordingly leads to increased ethanol consumption and preference (437).…”

Section: Water Intake Food Intake (Appetite) and Alcohol Intake (Prmentioning

confidence: 99%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

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334

297

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The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is relatively well understood, recent years have seen an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. Deletion of V1a or V1b receptor genes in mice revealed that the contributions of these receptors extend far beyond cardiovascular or hormone-secreting functions. Together with extensively developed pharmacological tools, genetically altered rodent models have advanced the understanding of a variety of AVP systems. Our report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.

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“…Further links to social behavior in humans were demonstrated by association of RS1-RS3 haplotypes with the personality trait reward dependence (13), association of RS3 with altruistic behavior (15), and a recent finding of an association between AVPR1A and pair bonding in humans (16). Interestingly, mice lacking AVPR1A display increased ethanol intake (17). …”

mentioning

confidence: 99%

The AVPR1A Gene and Substance Use Disorders: Association, Replication, and Functional Evidence

Maher

Vladimirov

Latendresse

et al. 2011

Biological Psychiatry

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Background The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms. Methods In 757 subjects, we performed association analysis between 1536 single nucleotide polymorphisms (SNPs) in 106 candidate genes and a drug use disorder diagnosis (DUD). Results Associations (p ≤ .0008) were detected with three SNPs in the arginine vasopressin 1A receptor gene, AVPR1A, with a gene-wise p value of 3 × 10−5. Bioinformatic evidence points to a role for rs11174811 (microRNA binding site disruption) in AVPR1A function. Based on literature implicating AVPR1A in social bonding, we tested spousal satisfaction as a mediator of the association of rs11174811 with the DUD. Spousal satisfaction was significantly associated with DUD in males (p <.0001). The functional AVPR1A SNP, rs11174811, was associated with spousal satisfaction in males (p = .007). Spousal satisfaction was a significant mediator of the relationship between rs11174811 and DUD. We also present replication of the association in males between rs11174811 and substance use in one clinically ascertained (n = 1399) and one epidemiologic sample (n = 2231). The direction of the association is consistent across the clinically-ascertained samples but reversed in the epidemiologic sample. Lastly, we found a significant impact of rs11174811 genotype on AVPR1A expression in a postmortem brain sample. Conclusions The findings of this study call for expansion of research into the role of the arginine vasopressin and other neuropeptide system variation in DUD liability.

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Alcohol preference in mice lacking the Avpr1a vasopressin receptor

Cited by 24 publications

References 55 publications

Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice

Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

The AVPR1A Gene and Substance Use Disorders: Association, Replication, and Functional Evidence

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