Alcohol‐Related Alterations in Placental Imprinted Gene Expression in Humans Mediate Effects of Prenatal Alcohol Exposure on Postnatal Growth

Carter, R. Colin; Chen, Jia; Li, Qian; Deyssenroth, Maya A.; Dodge, Neil C.; Wainwright, Helen; Molteno, Christopher D.; Meintjes, Ernesta M.; Jacobson, Joseph L.

doi:10.1111/acer.13808

Cited by 18 publications

(7 citation statements)

References 86 publications

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“…Moreover, the placenta imprinting status is very sensitive to early adverse environmental exposure. For example, altered placenta genomic imprinting has been observed in women exposed to endocrine disruptors, such as BPA and phthalates, as well as to residential air pollutants and alcohol consumption [97][98][99].…”

Section: Placental-specific Imprintingmentioning

confidence: 99%

Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics

2021

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Many complex traits or diseases, such as infectious and autoimmune diseases, cancer, xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the outcome of vaccination, show a differential susceptibility between males and females. In general, the female immune system responds more efficiently to pathogens. However, this can lead to over-reactive immune responses, which may explain the higher presence of autoimmune diseases in women, but also potentially the more adverse effects of vaccination in females compared with in males. Many clinical and epidemiological studies reported, for the SARS-CoV-2 infection, a gender-biased differential response; however, the majority of reports dealt with a comparable morbidity, with males, however, showing higher COVID-19 adverse outcomes. Although gender differences in immune responses have been studied predominantly within the context of sex hormone effects, some other mechanisms have been invoked: cellular mosaicism, skewed X chromosome inactivation, genes escaping X chromosome inactivation, and miRNAs encoded on the X chromosome. The hormonal hypothesis as well as other mechanisms will be examined and discussed in the light of the most recent epigenetic findings in the field, as the concept that epigenetics is the unifying mechanism in explaining gender-specific differences is increasingly emerging.

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Section: Placental-specific Imprintingmentioning

confidence: 99%

Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics

2021

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“…Imprinted gene expression analysis: Placental RNA was profiled using a custom-designed nCounter code set containing 109 established and putative imprinted genes (nanoString Technologies, Seattle, WA, USA) as previously described [ 32 ]. Briefly, RNA was hybridized to reporter and capture probes, and purified target-dual probe complexes were aligned and immobilized on imaging cartridges using an nCounter Prep Station II.…”

Section: Methodsmentioning

confidence: 99%

Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies

Deyssenroth

Escudero

et al. 2020

Genes

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Preeclampsia is a multi-systemic syndrome that presents in approximately 5% of pregnancies worldwide and is associated with a range of subsequent postpartum and postnatal outcomes, including fetal growth restriction. As the placenta plays a critical role in the development of preeclampsia, surveying genomic features of the placenta, including expression of imprinted genes, may reveal molecular markers that can further refine subtypes to aid targeted disease management. In this study, we conducted a comprehensive survey of placental imprinted gene expression across early and late onset preeclampsia cases and preterm and term normotensive controls. Placentas were collected at delivery from women recruited at the Magee-Womens Hospital prenatal clinics, and expression levels were profiled across 109 imprinted genes. We observed downregulation of placental Mesoderm-specific transcript (MEST) and Necdin (NDN) gene expression levels (false discovery rate (FDR) < 0.05) among early onset preeclampsia cases compared to preterm controls. No differences in placental imprinted gene expression were observed between late onset preeclampsia cases and term controls. While few studies have linked NDN to pregnancy complications, reductions in MEST expression levels, as observed in our study, are consistently reported in the literature in relation to various pregnancy complications, including fetal growth restriction, suggesting a potential role for placental MEST expression as a biosensor of an adverse in utero environment.

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“…Bien qu'il soit évident qu'une dysfonction placentaire puisse retentir sur le développement foetal compte tenu du rôle d'échange que joue cet organe, la démonstration d'une contribution placentaire dans le développement cérébral de l'enfant à naître était moins bien établie. Dans un contexte d'alcoolisation foetale, la méthylation de l'ADN et les conséquences sur l'expression génique placentaire peuvent se traduire par des atteintes du développement neurologique, comportemental et/ou staturo-pondéral de l'enfant [42,43]. Les travaux du groupe de Weinberg ont, de plus, montré l'existence, au cours d'une exposition in utero à l'alcool, d'une altération des taux de glucocorticoïdes placentaires, altération corrélée aux taux de glucocorticoïdes mesurés au niveau cérébral [44].…”

Section: Facteurs Placentaires Et Angiogenèse Cérébrale Foetaleunclassified

Alcoolisation fœtale

Sautreuil¹,

Laquerrière²,

Lecuyer³

et al. 2019

Med Sci (Paris)

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La consommation d’alcool au cours de la grossesse constitue une cause majeure de troubles du comportement et de handicap. Alors qu’il est possible pour un clinicien d’établir un diagnostic néonatal du syndrome d’alcoolisation fœtale, l’atteinte la plus sévère des troubles causés par l’alcoolisation fœtale (TCAF), une grande majorité des enfants échappe à un diagnostic précoce en raison de l’absence d’anomalies morphologiques évidentes. Plusieurs années de prise en charge sont alors perdues. Des avancées récentes ont permis d’établir l’existence d’un axe fonctionnel placenta-cerveau impliqué dans le contrôle de l’angiogenèse cérébrale, qui se trouve dérégulé chez les enfants exposés in utero à l’alcool. Une angiogenèse cérébrale normale étant un prérequis à l’établissement d’un neurodéveloppement correct, ces avancées ouvrent la voie à l’identification d’une nouvelle génération de biomarqueurs placentaires d’atteinte cérébrale pour le diagnostic précoce des enfants TCAF.

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Alcohol‐Related Alterations in Placental Imprinted Gene Expression in Humans Mediate Effects of Prenatal Alcohol Exposure on Postnatal Growth

Cited by 18 publications

References 86 publications

Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics

Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics

Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies

Alcoolisation fœtale

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