Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives

Liu, Szu-Yi; Tsai, I‐Ting; Hsu, Yin-Chou

doi:10.3390/ijms22105170

Cited by 78 publications

(70 citation statements)

References 260 publications

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“…The prevalence of alcohol consumption, opium use, and cigarette smoking as well as their side effects has always been one of the serious challenges to the health care system in most countries [19]. Several studies have shown detrimental effects of alcohol consumption, opium use, and cigarette smoking on the body organs, such as liver damage [20,21]. The current study aimed to examine the population of the Fasa Persian cohort study in the southern region of Iran to show the association between cigarette smoking, opium use, as well as alcohol consumption, with liver enzyme levels (AST, ALT, and ALP).…”

Section: Discussionmentioning

confidence: 99%

Examining the association between opium use, cigarette smoking and alcohol consumption with the liver enzyme levels in a population-based study: Fasa Persian cohort data

et al. 2022

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Objectives Opium use, cigarette smoking, and alcohol consumption are serious health problems in many countries including Iran. The present study aimed to examine the association between the opium use, cigarette smoking and alcohol consumption with liver enzyme levels in Southern Iran. This analytical cross-sectional study was conducted in 2020. The entire population of the Fasa Persian cohort study in the southern region of Iran was selected as the sample. Accordingly, 10,145 people participated in the study. Results Results indicated that there was a significant relationship between cigarette smoking and alcohol consumption with liver enzymes (AST, ALT, and ALP). There was also a significant relationship between inhaled opium and liver enzymes, but oral opium revealed no significant relationship with the activity of liver enzymes. Accordingly, policymakers of the health care system are recommended to hold educational programs to improve the health literacy level of the society and take effective preventative strategies in reducing the use of these substances.

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Section: Discussionmentioning

confidence: 99%

Examining the association between opium use, cigarette smoking and alcohol consumption with the liver enzyme levels in a population-based study: Fasa Persian cohort data

et al. 2022

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“…Alcohol is a recognized carcinogen and is closely related to the occurrence of liver cancer [ 80 ]. Therefore, we also attempted to further analyze the potential impact of alcohol intake on the protective effect of statins on hepatocarcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Statin Use and Risk of Hepatocellular Carcinoma

Wang

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Background. The use of statins is a potential protective factor against the development of hepatocellular carcinoma. Therefore, we conducted a meta-analysis to evaluate the contribution of statins to the risk of hepatocellular carcinoma. Methods. We searched for PubMed and EMBASE through January 2021. Results. Thirty-two studies (eighteen cohort, eleven case-control, and three randomized controlled trials) reporting 56,838 cases of hepatocellular carcinoma in 4,963,518 persons were included. Statin users were less likely to develop hepatocellular carcinoma than nonusers (adjusted odds ratio, 0.58; 95% CI: 0.51–0.67). Stratified analysis showed that statins reduced the risk of hepatocellular carcinoma in Asian and Western populations (odds ratio, 0.54 vs. 0.60). Besides, statins have protective effects against hepatocellular carcinoma after hepatitis B virus (odds ratio, 0.44; 95% CI: 0.22–0.85) and hepatitis C virus infections (odds ratio, 0.53; 95% CI: 0.49–0.57). Statins have protective effects on people with chronic liver disease (odds ratio, 0.52; 95% CI: 0.40–0.68) and on the general population (odds ratio, 0.60; 95% CI: 0.50–0.72). Lipophilic statins can prevent hepatocellular carcinoma (odds ratio, 0.51, 95% CI: 0.46–0.57), while hydrophilic statins cannot (odds ratio, 0.77, 95% CI: 0.58–1.02). The single-drug analyses showed that simvastatin (odds ratio, 0.53, 95% CI: 0.48–0.59), atorvastatin (odds ratio, 0.54, 95% CI: 0.45–0.64), rosuvastatin (odds ratio, 0.55, 95% CI: 0.37–0.83), lovastatin (odds ratio, 0.30, 95% CI: 0.15–0.62), and pitavastatin (odds ratio, 0.36, 95% CI: 0.17–0.75) had significant benefits. Further studies have shown that those in the high-dose group experienced better effects in preventing hepatocellular carcinoma (adjusted hazard ratio, 0.38 vs. 0.55). Further research found that the combined use of aspirin did not increase the chemoprevention effect of liver cancer (odds ratio, 0.57; 95% CI: 0.40–0.81). In addition, the preventive effect of statins improved with the extension of follow-up time (odds ratio, 0.54 vs. 0.65). Conclusion. Our meta-analysis shows that the use of statins is associated with a lower risk of liver cancer.

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“…Alcohol promotes inflammation, steatosis, and subsequently fibrosis by regulating multiple miRNAs. [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] In alcohol-fed murine models, miR-132 and miR-155 levels were upregulated in Kupffer cells. 92 MiR-155 enhances the proinflammatory effects of alcohol on Kupffer cells.…”

Section: Dna Methylation Histone Modifications and Non-coding Rna In ...mentioning

confidence: 99%