Examining the association between opium use, cigarette smoking and alcohol consumption with the liver enzyme levels in a population-based study: Fasa Persian cohort data

Bijani, Mostafa; Dehghan, Azizallah; Razavi, Saeed; Karimi, Shahnaz

doi:10.1186/s13104-021-05891-3

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…In this study, we contributed to revealing the association of urinary BPA with specific liver function indicators (i.e., ALT, AST, and GGT) was stronger in smokers and alcohol drinkers in the U.S. A previous population-based study (35) showed that smoking was related to a higher level of serum ALT and ALP, similar with our findings. It is noted that tobacco smoke is a risk factor for liver disease, chemical compounds in tobacco have cytotoxic potential which increases necroinflammation and liver fibrosis.…”

Section: Discussionsupporting

confidence: 88%

Urinary bisphenol A exposure in relation to liver function abnormalities among U.S. adults: results from the National Health and Nutrition Examination Survey, 2003-2016

Zhang,

Huang,

Wang

et al. 2023

Preprint

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SummaryBackgroundBisphenol A (BPA) is an endocrine-disrupting chemical that has been linked with various health outcomes. However, few studies using nationally representative data have assessed the association between BPA exposure with liver function. In addition, whether behavior characteristics of smoking and alcohol use modify such association has been underexplored.MethodsUsing data from seven cycles of the National Health and Nutrition Examination Surveys (NHANES) among 11,750 adults from 2003 to 2016, we investigated the relationship between urinary BPA with liver function indicators. BPA concentration in urine was measured by using high performance liquid chromatography with atmospheric pressure chemical ionization–mass spectrometry.We estimated BPA concentration after controlling for creatinine and normalized the asymmetrical distribution using natural logarithmic transformation (ln-BPA/Cr). Eight liver function indicators in serum were examined. Multivariate linear regression models were performed to explore the association between urinary BPA with changes in liver indicators. Stratified analyses examined whether these associations varied by sex, age, smoking, or drinking.FindingsOf the 11,750 participants (49.5% men), the mean age was 43.9 years. Per unit increment in ln-BPA/Cr was positively related to alkaline phosphotase (ALP) and total bilirubin (TBIL), while inversely with albumin (ALB). In quartile analysis, the highest BPA exposure was associated with higher aspartate aminotransferase (AST), ALP, and TBIL, while with decreased ALB (all Ptrend< 0.01). These associations for specific liver indicators (i.e., ALT, AST, Gamma-glutamyl transferase [GGT], and TBIL) were stronger in smokers and alcohol drinkers. Moreover, we found that BPA exposure with higher ALP in older adults (≥ 60 years) but no sex difference.InterpretationThis nationally representative study suggested that urinary BPA was associated with elevated AST, ALP, TBIL, and inversely with ALB among U.S. adults. The associations were more evident in smokers and drinkers but no sex difference. Better understanding of the mechanisms is needed for improving liver and planetary health.FundingNational Natural Science Foundation of China.

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Section: Discussionsupporting

confidence: 88%

Urinary bisphenol A exposure in relation to liver function abnormalities among U.S. adults: results from the National Health and Nutrition Examination Survey, 2003-2016

Zhang,

Huang,

Wang

et al. 2023

Preprint

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“…Several factors cause increased ALP levels. Tenofovir, inhaled opium, and cigarette smoking cause elevated ALP levels (Abongwa et al, 2022;Bijani et al, 2022). Tenofovir is used to prevent and treat HIV/AIDS as well as chronic hepatitis B.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, prevalence, and associated factors of oral candidiasis in HIV patients from southwest Iran in post-highly active antiretroviral therapy era

Erfaninejad

Mahmoudabadi²,

Maraghi³

et al. 2022

Front. Microbiol.

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BackgroundOral candidiasis (OC) is one of the most common opportunistic fungal infections among people living with HIV/AIDS (PLWHA). The prevalence of OC and Candida profiles among HIV-infected patients might be changing in the era of Highly Active Antiretroviral Therapy (HAART). This study aimed to identify Candida spp., determine OC prevalence and associated risk factors for PLWHA.Materials and methodsOral candidiasis prevalence was explored in oral swabs of 276 patients who referred for consultation at Behavioral Diseases Counseling Center (BDCC). Clinical symptoms, culture and molecular assays were used for OC detection. In statistical analysis, we assessed socio-demographic characteristics, clinical information and treatment history of some infections.ResultsThe overall prevalence of OC was 41%. Candida albicans (64.6%) was the most common species, followed by C. glabrata (26.5%) and C. dubliniensis (19.5%). Candida famata, C. africana, and C. stellatoidea as the first fungi isolated from OC in PLWHA from southwest Iran. In 36.3% of patients, mixed cultures of more than one species were observed. Body mass index (BMI) (OR = 0.947; CI = 0.89–0.99; p = 0.045) and CD4 count ≤ 200 cells/mm3 (OR = 4.365; CI = 1.73–10.98; p = 0.002) were the predictors of OC in the final model of multiple logistic regression analysis. Education level, addiction status, sexual behaviors, chest X-ray, other infections and WHO clinical stage were other important risk factors for OC.ConclusionOral candidiasis remains a significant opportunistic infection in post-HAART era among PLWHA. Despite the increasing prevalence of NAC species, C. albicans (64.6%) was still the predominant species. Our results showed that low BMI with OC indicates treatment failure (i.e., failure to increase CD4 count or suppress viral load). Also, low CD4 counts (≤200 cells/mm3) in HIV patients show an impaired immune status, and our findings emphasize that OC can be a clinical indicator of HIV infection in individuals who do not know their HIV status or have failed treatment.

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Royal Jelly bioactive compounds and exercise improved cardiomyopathy and redox status in patients under methadone maintenance therapy: Randomized clinical trial

Sargazi

Taghian

2023

Journal of Herbal Medicine

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Examining the association between opium use, cigarette smoking and alcohol consumption with the liver enzyme levels in a population-based study: Fasa Persian cohort data

Cited by 4 publications

References 27 publications

Urinary bisphenol A exposure in relation to liver function abnormalities among U.S. adults: results from the National Health and Nutrition Examination Survey, 2003-2016

Urinary bisphenol A exposure in relation to liver function abnormalities among U.S. adults: results from the National Health and Nutrition Examination Survey, 2003-2016

Epidemiology, prevalence, and associated factors of oral candidiasis in HIV patients from southwest Iran in post-highly active antiretroviral therapy era

Royal Jelly bioactive compounds and exercise improved cardiomyopathy and redox status in patients under methadone maintenance therapy: Randomized clinical trial

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