Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress

Caldwell, Elizabeth E.; Riccio, David C.

doi:10.1016/j.alcohol.2010.02.012

Cited by 50 publications

(38 citation statements)

References 53 publications

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“…However, once the physical threat is no longer present in the environment, animals may seek drug in an attempt to self-medicate. This idea is consistent with increased alcohol intake when access to alcohol is offered 2-h post-defeat (Caldwell and Riccio 2010). By contrast, chronic, unpredictable stressors that are unavoidable may heighten reward sensitivity or produce attempts to self-medicate resulting in facilitated drug taking and seeking behaviors.…”

Section: Potential Mechanisms Of Social Influences On Drug Abuse-relasupporting

confidence: 61%

“…The decrease in alcohol consumption is consistent with the general suppressant effects that stressors have on ongoing behavior (e.g., Meerlo et al 1996). In contrast, when access to alcohol is delayed 2 h post-defeat, rats exhibit an increase in alcohol intake (Caldwell and Riccio 2010). Croft et al (2005) also found a delayed increase in alcohol preference in a selected subgroup of low alcohol-preferring C57/BL/10 mice with a history of repeated SD that emerged about 2 weeks after the last defeat episode.…”

Section: Social Experiences Proximal In Time To the Drug Experience Bmentioning

confidence: 99%

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Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction

2012

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Rationale Social factors are important determinants of drug dependence and relapse. Objectives We reviewed preclinical literature examining the role of social experiences from early life through the development of drug dependence and relapse, emphasizing two aspects of these experiences: 1) whether the social interaction is appetitive or aversive and 2) whether the social interaction occurs within or outside of the drug-taking context. Methods The models reviewed include neonatal care, isolation, social defeat, chronic subordination, and prosocial interactions. We review results from these models in regard to effects on self-administration and conditioned place preference established with alcohol, psychostimulants, and opiates. Results We suggest that in general, when the interactions occur outside of the drug-taking context, prosocial interactions are protective against drug abuse-related behaviors whereas social stressors facilitate these behaviors. By contrast, positive or negative social interactions occurring within the drug-taking context may interact with other risk factors to enhance or inhibit these behaviors. Conclusions Despite differences in the nature and complexity of human social behavior compared to other species, the evolving animal literature provides useful models for understanding social influences on drug abuse-related behavior that will allow for research on the behavioral and biological mechanisms involved. The models have contributed to understanding social influences on initiation and maintenance of drug use, but more research is needed to understand social influences on drug relapse.

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Section: Potential Mechanisms Of Social Influences On Drug Abuse-relasupporting

confidence: 61%

Section: Social Experiences Proximal In Time To the Drug Experience Bmentioning

confidence: 99%

Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction

2012

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“…However, on the day after the final defeat exposure, rats trained with a 4-hour interval between defeat and operant sessions showed a significant elevation in alcohol intake, suggesting persistent effects of a history of social stress (van Erp and Miczek, 2001). Milder, 5-minute defeat exposure paradigms have yielded different results, with modest elevation of home cage 6% alcohol consumption observed both the week of and the week after stress exposure when alcohol access was provided 2 hours after the defeat session (Caldwell and Riccio, 2010). Repeated, but not single, mild social defeat encounters did not alter home cage 8% alcohol intake on defeat days but rather yielded increased alcohol intake in the second week after defeat exposure (Croft et al, 2005).…”

Section: Effects Of Adult Social Psychological Stress: Social Defeatmentioning

confidence: 99%

Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder

2012

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Drug abuse and dependence present significant health burdens for our society, affecting roughly 10% of the population. Stress likely contributes to the development and persistence of drug use; for example, rates of substance dependence are elevated among individuals diagnosed with post-traumatic stress disorder (PTSD). Thus, understanding the interaction between stress and drug use, and associated neuroadaptations, is key for developing therapies to combat substance use disorders. For this purpose, many rodent models of the effects of stress exposure on substance use have been developed; the models can be classified according to three categories of stress exposure: developmental, adult nonsocial, and adult social. The present review addresses preclinical findings on the effect of each type of trauma on responses to and self-administration of drugs of abuse by focusing on a key exemplar for each category. In addition, the potential efficacy of targeting neuropeptide systems that have been implicated in stress responses and stress system neuroadaptation in order to treat comorbid PTSD and substance abuse will be discussed.

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“…Both clinical and preclinical evidence suggest that alcohol consumption can be elevated by acute and chronic stress under some circumstances (Caldwell and Riccio, 2010; Volpicelli et al, 1990), although the relationship between alcohol use and stressful events has been shown to be quite complex (see Uhart and Wand, 2008 for references and review). It has been suggested that stress is most strongly associated with heavy drinking in adolescence, with this association becoming considerably weaker later in life (Aseltine and Gore, 2000).…”

Section: Introductionmentioning

confidence: 99%

Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats

Spear

2012

Pharmacology Biochemistry and Behavior

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Repeated exposure to stressors has been found to increase anxiety-like behavior in laboratory rodents, with the social anxiety induced by repeated restraint being extremely sensitive to anxiolytic effects of ethanol in both adolescent and adult rats. No studies, however, have compared social anxiogenic effects of acute stress or the capacity of ethanol to reverse this anxiety in adolescent and adult animals. Therefore, the present study was designed to investigate whether adolescent [postnatal day (P35)] Sprague-Dawley rats differ from their adult counterparts (P70) in the impact of acute restraint stress on social anxiety and in their sensitivity to the social anxiolytic effects of ethanol. Animals were restrained for 90 min, followed by examination of stress- and ethanol-induced (0, 0.25, 0.5, 0.75, and 1 g/kg) alterations in social behavior using a modified social interaction test in a familiar environment. Acute restraint stress increased anxiety, as indexed by reduced levels of social investigation at both ages, and decreased social preference among adolescents. These increases in anxiety were dramatically reversed among adolescents by acute ethanol. No anxiolytic-like effects of ethanol emerged following restraint stress in adults. The social suppression seen in response to higher doses of ethanol was reversed by restraint stress in animals of both ages. To the extent that these data are applicable to humans, the results of the present study provide some experimental evidence that stressful life events may increase the attractiveness of alcohol as an anxiolytic agent for adolescents.

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Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress

Cited by 50 publications

References 53 publications

Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction

Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction

Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder

Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats

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