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Aggression was only modestly affected by CIT in the first 2 weeks of treatment. However, by day 17 of CIT treatment, alcohol-heightened aggressive behavior was abolished, while baseline aggression remained stable. These data lend support for the role of the 5-HT transporter in the control of alcohol-related aggressive behavior, and the time course of effects suggests that a change in density of 5HT(1A) autoreceptors is necessary before antidepressant drugs produce beneficial outcomes.

In the present study, the authors examined the effects of diazepam (Valium) on various physical, social, and emotional variables within the framework of a task designed to test risk-taking behavior. Participants received either 10 mg of diazepam or a placebo. After the participants tasted strong-flavored liquids, they were able to engage in a risky behavior (i.e., drinking from a confederate's "used" water bottle). Half the participants received additional verbal pressure to drink from the bottle. The authors expected that diazepam would increase health-risk behavior, but the results were inconsistent with that prediction. The second goal of the experiment was to explore diazepam's effects on arousal, mood, social anxiety, and taste. Diazepam users exhibited differences in taste perception and social anxiety, which might in part explain the health-risk results.

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