Alcohol Sensitizes Cerebral Responses to the Odors of Alcoholic Drinks: An fMRI Study

Bragulat, Veronique; Džemidžić, Mario; Talavage, Thomas M.; Davidson, Dena; O’Connor, Sean; Kareken, David A.

doi:10.1111/j.1530-0277.2008.00693.x

Cited by 62 publications

(85 citation statements)

References 74 publications

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“…This finding is in line with previous research 1,21,70 showing an enhanced cueinduced brain response in this area, which may mediate an attentional bias toward drug cues. Interestingly, the observed brain response here is more superior than the previous finding from our group 1 ; this might be an effect of sample size or of differences in the covariables used for correction (local gray matter volume, as well as age, sex, smoking behavior, and mood effects).…”

Section: Commentsupporting

confidence: 82%

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

Beck

Wüstenberg

Genauck

et al. 2012

Arch Gen Psychiatry

253

242

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Context:In alcohol-dependent patients, brain atrophy and functional brain activation elicited by alcohol-associated stimuli may predict relapse. However, to date, the interaction between both factors has not been studied.Objective: To determine whether results from structural and functional magnetic resonance imaging are associated with relapse in detoxified alcohol-dependent patients.Design: A cue-reactivity functional magnetic resonance experiment with alcohol-associated and neutral stimuli. After a follow-up period of 3 months, the group of 46 detoxified alcohol-dependent patients was subdivided into 16 abstainers and 30 relapsers. Participants: A total of 46 detoxified alcoholdependent patients and 46 age-and sex-matched healthy control subjects Main Outcome Measures: Local gray matter volume, local stimulus-related functional magnetic resonance imaging activation, joint analyses of structural and functional data with Biological Parametric Mapping, and connectivity analyses adopting the psychophysiological interaction approach.Results: Subsequent relapsers showed pronounced atrophy in the bilateral orbitofrontal cortex and in the right medial prefrontal and anterior cingulate cortex, compared with healthy controls and patients who remained abstinent. The local gray matter volume-corrected brain response elicited by alcohol-associated vs neutral stimuli in the left medial prefrontal cortex was enhanced for subsequent relapsers, whereas abstainers displayed an increased neural response in the midbrain (the ventral tegmental area extending into the subthalamic nucleus) and ventral striatum. For alcohol-associated vs neutral stimuli in abstainers compared with relapsers, the analyses of the psychophysiological interaction showed a stronger functional connectivity between the midbrain and the left amygdala and between the midbrain and the left orbitofrontal cortex.Conclusions: Subsequent relapsers displayed increased brain atrophy in brain areas associated with error monitoring and behavioral control. Correcting for gray matter reductions, we found that, in these patients, alcohol-related cues elicited increased activation in brain areas associated with attentional bias toward these cues and that, in patients who remained abstinent, increased activation and connectivity were observed in brain areas associated with processing of salient or aversive stimuli. Psychiatry. 2012;69(8):842-853 Arch Gen

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Section: Commentsupporting

confidence: 82%

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

Beck

Wüstenberg

Genauck

et al. 2012

Arch Gen Psychiatry

253

242

View full text Add to dashboard Cite

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“…2 sLORETA contrast analysis before and after alcohol intake (P \ 0.05). a Alpha1, b alpha2, c beta3 and d gamma cortex, posterior cingulate cortex, retrosplenial area, and the precuneus are influenced by seeing or smelling alcohol cues (Bragulat et al 2008;Hermann et al 2006;Tapert et al 2003). Previous studies also showed that these brain areas, namely orbitofrontal cortex, ventromedial frontal cortex, subcallosal anterior cingulate cortex, posterior cingulate cortex, retrosplenial area, and the precuneus are also important in distress in general (Blood et al 1999;Damasio 1996;Dias et al 1996;Wheeler et al 1993) and also for tinnitus-related distress (Muhlau et al 2006;Vanneste et al 2010a).…”

Section: Discussionmentioning

confidence: 92%

“…subjects' drinks of choice) and non-appetitive odors (e.g. grass, leather) is characterized by activity in the orbitofrontal cortex, ventromedial frontal cortex, subcallosal anterior cingulate cortex, posterior cingulate cortex, retrosplenial area, and the precuneus in heavy drinkers (Bragulat et al 2008). Visual images of alcoholic beverages induced activity in the orbitofrontal cortex, ventromedial frontal cortex, and posterior cingulate (Hermann et al 2006).…”

Section: Introductionmentioning

confidence: 99%

The Use of Alcohol as a Moderator for Tinnitus-Related Distress

Vanneste

Ridder

2011

Brain Topogr

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Tinnitus is an auditory phantom percept with a tone, hissing, or buzzing sound in the absence of any objective physical sound source. Persons with tinnitus engage in a number of health behaviors to manage tinnitus. This can go from prescription medication, masking devices, behavioral training techniques to cortical implants. Potentially less adaptive methods of coping with tinnitus, such as the use of alcohol, are poorly studied. The purpose of this study was to further explore the neurobiological mechanism of tinnitus improvement by the use of alcohol. We observed differences in the alpha, beta and gamma frequency band when comparing resting-state EEG before and after alcohol intake. More precisely increased synchronized alpha1 activity was found in the posterior cingulate cortex and decreased synchronized alpha2 activity was demonstrated in orbitofrontal cortex, ventrolateral prefrontal cortex and subcallosal anterior cingulate cortex after alcohol intake. Increased synchronized activity was found in a region between the pregenual and dorsal anterior cingulate cortex and the left insula for beta and decreased activity in the precuneus after alcohol intake. For the gamma frequency band decreased synchronized activity in the precuneus and the posterior cingulate cortex was demonstrated after alcohol intake. Region of interest analyses in auditory cortices and parahippocampal area revealed however no differences in the different frequency bands before and after alcohol consumption.

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“…No effect of parental alcoholism in processing of reward in the ventral striatum Bragulat et al (2008) Hazardous drinkers Increased limbic network activation to alcohol cues following small dose of alcohol Filbey et al (2008) Heavy drinking individuals Alcohol taste vs. appetitive control taste elicited response in the reward system (prefrontal cortex, striatum, ventral tegmental area ⁄ substantia nigra) Gilman and Hommer (2008) Treatment seeking alcohol-dependent patients vs. healthy controls Activation differences between the positive and negative as well as alcohol-related images among the alcoholics Myrick et al (2008) Nontreatment seeking alcohol-dependent individuals vs. social drinkers Naltrexone and ondansetron reduced alcohol cue-induced activation of the ventral striatum Beck et al (2009) Treatment seeking alcohol-dependent patients vs. healthy controls Link between high impulsivity and reduced ventral striatal activation to nondrug reward MRI Morphometry Jernigan et al (1991) Treatment seeking alcohol-dependent patients vs. healthy controls Increases in subarachnoid CSF volume and ventricular enlargement Pfefferbaum et al (1992) Treatment seeking alcohol-dependent patients vs. healthy controls…”

Section: Structural Gray and White Matter Changesmentioning

confidence: 99%

Alcohol and the Human Brain: A Systematic Review of Different Neuroimaging Methods

Bühler

Mann

2011

Alcoholism: Clinical and Experimental Research

275

197

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There has been tremendous progress in the development of imaging technologies. Use of these technologies has clearly demonstrated the structural and functional brain abnormalities that can occur with chronic alcohol use. The study of the alcoholic brain provides an heuristic model which furthers our understanding of neurodegenerative changes in general, as well as their partial reversibility with sustained abstinence. Additionally, functional imaging is poised to become an important tool for generating predictions about individual brain functioning, which can then be used as a basis for personalized medicine.

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Alcohol Sensitizes Cerebral Responses to the Odors of Alcoholic Drinks: An fMRI Study

Cited by 62 publications

References 74 publications

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

The Use of Alcohol as a Moderator for Tinnitus-Related Distress

Alcohol and the Human Brain: A Systematic Review of Different Neuroimaging Methods

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