Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy

O’Mahony, Constantinos; Mohiddin, Saidi A; Knight, Charles

doi:10.15420/icr.2011.9.2.108

Cited by 4 publications

(2 citation statements)

References 90 publications

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“…28 The balloon remains inflated for 5-10 min post-ethanol injection to prevent reflux in the LAD and to enhance delivery at the target myocardium. 29 After withdrawal of the balloon catheter, a final angiogram is obtained to document complete occlusion of the septal branch and normal flow in the LAD. At least 48-72 h of hemodynamic and arrhythmia monitoring in the coronary care unit is required.…”

Section: New Approach For Ptsmamentioning

confidence: 99%

Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy

Maekawa

Akita

Takanashi

2018

Circ J

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Hypertrophic cardiomyopathy (HCM) is a complex and relatively common genetic cardiac disease that has been the subject of intense investigation for over 50 years. Most patients with HCM are asymptomatic, but some develop symptoms, often many years after the appearance of electrocardiographic or echocardiographic evidence of left ventricular hypertrophy. Symptoms due to the left ventricular outflow tract obstruction frequently worsen over time, requiring septal reduction therapy (SRT) despite optimal medical therapy. Percutaneous transluminal septal myocardial ablation (PTSMA) and surgical myectomy are collectively known as SRT. In this review, we will focus on the emerging concept and practical implication of SRT and the available evidence on either PTSMA or surgical myectomy in the literature.

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Section: New Approach For Ptsmamentioning

confidence: 99%

Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy

Maekawa

Akita

Takanashi

2018

Circ J

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“…Valsalva), reduced afterload (vasodilators) and positive inotropes. [4]. Based on the severity of obstruction patients can experience a reduction in cardiac output, worsening of mitral regurgitation, diastolic dysfunction leading to increase in LV end diastolic pressure and affect coronary blood flow and some degree of arrhythmia (figure 2).…”

Section: Introductionmentioning

confidence: 99%

Alcohol Septal Ablation: A useful tool in our arsenal against hypertrophic obstructive cardiomyopathy

Savarimuthu

Harky

2020

Preprint

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Objective Affecting 1 in 500 individuals; Hypertrophic cardiomyopathy (HCM) is an autosomal dominant cardiovascular disorder which is prevalent throughout the world. Surgical myectomy and alcohol septal ablation (ASA) are two methods currently used for the management of drug refractory Hypertrophic obstructive cardiomyopathy (HOCM). ASA may prove to be a useful, less invasive tool when confronting patients with HOCM especially those who are more elderly or deemed to be a higher surgical risk. Methods Electronic literature search was conducted to identify relevant articles that discussed invasive methods to treat drug refractory HOCM. No limits were placed on timing of the publication or the type of article. Key words and MeSH terms were used to conduct the search and the results were summarized in the relevant section. Results Current evidence suggests that alcohol septal ablation is a safe and effective procedure in treating patients with HOCM with similar short-and long-term outcomes when compared with surgical myectomy. Selection of patient with appropriate assessment is the key for satisfactory outcomes. Conclusion ASA has been shown to be a safe and reliable procedure; advanced imaging techniques and dedicated multi-disciplinary teams can be used to carefully select patients with HOCM. Though surgical myectomy is recommended as gold standard treatment for drug refractory HOCM, however, ASA may play an increasing role in the near future due an ageing population; both ASA and SM can have a synergistic effect in treating those who are affected by HOCM.

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Alcohol septal ablation: A useful tool in our arsenal against hypertrophic obstructive cardiomyopathy

Savarimuthu

Harky

2020

J Card Surg

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Objective Affecting 1 in 500 individuals; hypertrophic cardiomyopathy is an autosomal dominant cardiovascular disorder which is prevalent throughout the world. Surgical myectomy (SM) and alcohol septal ablation (ASA) are two methods currently used for the management of drug refractory hypertrophic obstructive cardiomyopathy (HOCM). ASA may prove to be a useful, less invasive treatment in patients with HOCM Methods Electronic literature search was conducted to identify articles that discussed methods to treat drug refractory HOCM. No limits were placed on timing of the publication or the type of article. Keywords and MeSH terms were used and the results were summarized in the relevant section. Results Current evidence suggests that alcohol septal ablation is a safe and effective procedure in treating patients with HOCM with similar short‐ and long‐term outcomes when compared with SM. Conclusion ASA has been shown to be a safe and reliable procedure; imaging techniques and dedicated multi‐disciplinary teams can be used to select patients with HOCM. Though SM is recommended as gold standard treatment for drug refractory HOCM, ASA may play an increasing role in the near future due an ageing population; both ASA and SM can have a beneficial role in treating those who are affected by HOCM when the appropriate group of patients are selected for each intervention.

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Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy

Cited by 4 publications

References 90 publications

Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy

Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy

Alcohol Septal Ablation: A useful tool in our arsenal against hypertrophic obstructive cardiomyopathy

Alcohol septal ablation: A useful tool in our arsenal against hypertrophic obstructive cardiomyopathy

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