Alcoholic liver disease

Blázovics, Anna

doi:10.1016/b978-0-12-816488-4.00010-3

Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases 2021

DOI: 10.1016/b978-0-12-816488-4.00010-3

|View full text |Cite

Alcoholic liver disease

Anna Blázovics

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Influence of Combined Effect of Constant Illumination and Chronic Alcohol Intoxication on Hepatocyte Ultrastructure in Male and Female Wistar Rats

Areshidze,

Mikhaleva,

Kakturskiy

et al. 2023

Ulyanovsk Medico-biological Journal

View full text Add to dashboard Cite

Light pollution causes melatonin deficiency and circadian rhythm disruption. Thus, it is associated with hepatopathy. Circadian rhythm disruption increases liver damage from alcohol and the severity of alcoholism. The aim of the study was to examine the combined effect of constant illumination and chronic alcohol intoxication (CAI) on hepatocyte ultrastructure in male and female rats. Materials and Methods. The study was carried out on 120 male and 80 female Wistar outbred rats aged 6 months. The experiment lasted 3 weeks. Differences in morphological patterns of hepatocyte ultrastructure were visually assessed. The percentage of hepatocytes containing lipid vacuoles was calculated. Results. Constant illumination and chronic alcohol intoxication caused allostasis. Hepatocyte edema, mitochondria swelling, karyopyknosis, fatty degeneration, and hepatocyte death were detected in the liver cells of male and female rats. The above-mentioned pathological changes were less severe in females. Moreover, collagen layers did not proliferate into the liver tissues in female rats. So, we can conclude that the combined effect of constant illumination and CAI do not lead to inflammatory changes and architectural distortion in the liver of female rats. Taking into account the morphological picture of the liver of male and female rats and a number of biochemical parameters that describe its functional state, the obtained data on gender differences in the hepatocyte ultrastructure in rats exposed to CAI and constant illumination allow us to report that hepatocyte adaptation to stress is more successful in female rats than in male ones.

show abstract

Influence of Combined Effect of Constant Illumination and Chronic Alcohol Intoxication on Hepatocyte Ultrastructure in Male and Female Wistar Rats

Areshidze,

Mikhaleva,

Kakturskiy

et al. 2023

Ulyanovsk Medico-biological Journal

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Alcoholic liver disease

Cited by 1 publication

References 123 publications

Influence of Combined Effect of Constant Illumination and Chronic Alcohol Intoxication on Hepatocyte Ultrastructure in Male and Female Wistar Rats

Influence of Combined Effect of Constant Illumination and Chronic Alcohol Intoxication on Hepatocyte Ultrastructure in Male and Female Wistar Rats

Contact Info

Product

Resources

About