Alcoholics' impaired lymphocyte response is caused by alcohol

Stefanini, Giuseppe Francesco; Castelli, E; Foschi, Francesco Giuseppe; Hrelia, Silvana; Biagi, Pierluigi; Celadon, M.; Bordoni, Alessandra; Gasbarrini, Giovanni

doi:10.1016/0016-5085(94)90445-6

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Alcohol produces alterations in membrane lipid composition (38) that could affect intracellular signaling in response to the attachment of growth factors and hormones to their cognate cell surface receptors. Thus chronic alcohol consumption has been shown to impair [Ca 2ϩ ] i signaling in human lymphocytes (39). Further, Sasaki and Wands recently reported that long-term ethanol consumption impairs the transduction of signals from cell surface insulin receptors to intracellular regulatory proteins during liver regeneration (40).…”

Section: Discussionmentioning

confidence: 99%

Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration.

Zhang¹,

Hornsfield²,

Farrell³

1996

J. Clin. Invest.

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Ethanol, Liver Regeneration and [Ca] i transients. These changes were not due to an effect on the Ins(1,4,5) P 3 receptor on the endoplasmic reticulum or to a decrease in the size of the Ins(1,4,5) P 3 -mobilizable intracellular Ca 2 ϩ store. Further, mobilization of the same Ca 2 ϩ store by 2,5-di-tert -butylhydroquinone or thapsigargin restored the ability of hepatocytes from ethanol-fed rats to proliferate when exposed to EGF. It is concluded that chronic ethanol consumption inhibits liver regeneration by a mechanism that is, at least partly, the result of impaired receptor-operated [Ca 2 ϩ ] i signaling due to reduced generation of

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Section: Discussionmentioning

confidence: 99%

Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration.

Zhang¹,

Hornsfield²,

Farrell³

1996

J. Clin. Invest.

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show abstract

“…Experiences in both animals and humans have shown a reduction in the number and function of peripheral T cells, and inhibition of the activation of T cells, and an increase in apoptosis. In addition, a reduction of peripheral B cells with alteration of the production of immunoglobulins has been documented 22–24 …”

Section: Infections Aud and Covid‐19mentioning

confidence: 99%

“…Ethanol is able to interact at different levels, acting both on natural or innate immunity (phagocytosis, natural killer cells and complement) and on specific or acquired immunity. 22 , 23 , 24 Experiences in both animals and humans have shown a reduction in the number and function of peripheral T cells, and inhibition of the activation of T cells, and an increase in apoptosis. In addition, a reduction of peripheral B cells with alteration of the production of immunoglobulins has been documented.…”

Section: Infections Aud and Covid‐19mentioning

confidence: 99%

“…In addition, a reduction of peripheral B cells with alteration of the production of immunoglobulins has been documented. 22 , 23 , 24 …”

Section: Infections Aud and Covid‐19mentioning

confidence: 99%

“…Chronic alcohol consumption compromises the entire immunological system, 22,23 increasing the risk of severe virus infections by strengthening the inflammatory reaction. Ethanol is able to interact at different levels, acting both on natural or innate immunity (phagocytosis, natural killer cells and complement) and on specific or acquired immunity 22–24 . Experiences in both animals and humans have shown a reduction in the number and function of peripheral T cells, and inhibition of the activation of T cells, and an increase in apoptosis.…”

Section: Infections Aud and Covid‐19mentioning

confidence: 99%

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Alcohol use disorder in the COVID‐19 era: Position paper of the Italian Society on Alcohol (SIA)

Testino

Vignoli²,

Patussi

et al. 2021

Addiction Biology

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Coronavirus disease 2019 (COVID‐19) first emerged in China in November 2019. Most governments have responded to the COVID‐19 pandemic by imposing a lockdown. Some evidence suggests that a period of isolation might have led to a spike in alcohol misuse, and in the case of patients with alcohol use disorder (AUD), social isolation can favour lapse and relapse. The aim of our position paper is to provide specialists in the alcohol addiction field, in psychopharmacology, gastroenterology and in internal medicine, with appropriate tools to better manage patients with AUD and COVID‐19,considering some important topics: (a) the susceptibility of AUD patients to infection; (b) the pharmacological interaction between medications used to treat AUD and to treat COVID‐19; (c) the reorganization of the Centre for Alcohol Addiction Treatment for the management of AUD patients in the COVID‐19 era (group activities, telemedicine, outpatients treatment, alcohol‐related liver disease and liver transplantation, collecting samples); (d) AUD and SARS‐CoV‐2 vaccination. Telemedicine/telehealth will undoubtedly be useful/practical tools even though it remains at an elementary level; the contribution of the family and of caregivers in the management of AUD patients will play a significant role; the multidisciplinary intervention involving experts in the treatment of AUD with specialists in the treatment of COVID‐19 disease will need implementation. Thus, the COVID‐19 pandemic is rapidly leading addiction specialists towards a new governance scenario of AUD, which necessarily needs an in‐depth reconsideration, focusing attention on a safe approach in combination with the efficacy of treatment.

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Wine and health: a review and perspective

Finkel¹

1996

Journal of Wine Research

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Alcoholics' impaired lymphocyte response is caused by alcohol

Cited by 5 publications

References 5 publications

Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration.

Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration.

Alcohol use disorder in the COVID‐19 era: Position paper of the Italian Society on Alcohol (SIA)

Wine and health: a review and perspective

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