2015
DOI: 10.1177/1470320315595568
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Aldosterone effects on glomerular structure and function

Abstract: Experimental evidence suggests that aldosterone directly contributes to organ damage by promoting cell growth, fibrosis, and inflammation. Based on these premises, this work aimed to assess the glomerular effects of aldosterone, alone and in combination with salt

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Cited by 21 publications
(12 citation statements)
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References 54 publications
(90 reference statements)
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“…Aldosterone is an essential mineralocorticoid hormone directly involved in the regulation of sodium absorption and potassium excretion in the kidney, salivary glands, sweat glands, and colon (33). Elevated levels of aldosterone are known to alter glomerular structure and function via pro-oxidative and profibrotic changes (34). Hence, aldosterone increases glomerular permeability to albumin, leading to increased protein urinary excretion.…”
Section: Discussionmentioning
confidence: 99%
“…Aldosterone is an essential mineralocorticoid hormone directly involved in the regulation of sodium absorption and potassium excretion in the kidney, salivary glands, sweat glands, and colon (33). Elevated levels of aldosterone are known to alter glomerular structure and function via pro-oxidative and profibrotic changes (34). Hence, aldosterone increases glomerular permeability to albumin, leading to increased protein urinary excretion.…”
Section: Discussionmentioning
confidence: 99%
“…Similar findings were reported in podocytes [ 174 ] and in cardiomyocytes [ 175 ]. Locally, aldosterone triggers a vicious cycle that promotes AngII/AT1R effects as it mediates part of Ang II effects [ 176 ], increases tissue ACE and AT1R [ 177 ], and reduces tissue ACE2 [ 178 , 179 ]. Moreover, together with Ang II, aldosterone promotes oxidative stress, fibrosis, and apoptosis.…”
Section: Diabetes the Activation And Imbalance Of The Renin-angiomentioning
confidence: 99%
“…Thus, stress could be an important cause of the increase in the aldosterone levels 3,4 . Aldosterone has been associated with hypertension, metabolic syndrome, 5,6 and renal injury 7,8 . It also causes inflammation, oxidative stress, fibrosis, mesangial proliferation, and podocyte injury, 9,10 as well as glomerular hypertrophy, mesangial expansion inducing changes in the filtration process 7 …”
Section: Introductionmentioning
confidence: 99%