Aldosteronoma in a child with localization by adrenal vein aldosterone: Collective review of the literature

Kafrouni, George; Oakes, Marilyn D.; Lurvey, Arthur; DeQuattro, Vincent

doi:10.1016/s0022-3468(75)80096-0

Cited by 16 publications

(3 citation statements)

References 14 publications

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“…Aldosterone-producing adenoma is very rare in children (28). Five patients were identified in this review comprising 1.6% of all ACT cases (29,30).…”

Section: Clinical Featuresmentioning

confidence: 99%

Adrenocortical tumors in children

Ribeiro

Michalkiewicz

Figueiredo

et al. 2000

Braz J Med Biol Res

111

117

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Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer (p53 mutations) and selected genetic syndromes (Beckwith-Wiedemann syndrome) have been associated with childhood ACT in general but not with the Brazilian counterpart. Most of the affected children are young girls with classic endocrine syndromes (virilizing and/or Cushing). Levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (DHEA-S), which are abnormal in approximately 90% of the cases, provide the pivotal clue to a diagnosis of ACT. Typical imaging findings of pediatric ACT consist of a large, well-defined suprarenal tumor containing calcifications with a thin capsule and central necrosis or hemorrhage. The pathologic classification of pediatric ACT is troublesome. Even an experienced pathologist can find it difficult to differentiate carcinoma from adenoma. Surgery is the single most important procedure in the successful treatment of ACT. The role of chemotherapy in the management of childhood ACT has not been established although occasional tumors are responsive to mitotane or cisplatin-containing regimens. Because of the heterogeneity and rarity of the disease, prognostic factors have been difficult to establish in pediatric ACT. Patients with incomplete tumor resection or with metastatic disease at diagnosis have a dismal prognosis. In patients with localized and completely resected tumors, the size of the tumor has predictive value. Patients with large tumors have a much higher relapse rate than those with small tumors.

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“…Aldosterone-producing adenoma is very rare in children (28). Five patients were identified in this review comprising 1.6% of all ACT cases (29,30).…”

Section: Clinical Featuresmentioning

confidence: 99%

Adrenocortical tumors in children

Ribeiro

Michalkiewicz

Figueiredo

et al. 2000

Braz J Med Biol Res

111

117

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“…Since then only six other cases have been reported [3]. All were females except for one ll-year-old black male [3]. The cure rate after adrenalectomy is 100% in children [3].…”

Section: Discussionmentioning

confidence: 99%

“…The first case of an adrenal adenoma causing primary aldosteronism in children was reported in 1959 by Orndahl et al [2]. Since then only six other cases have been reported [3]. All were females except for one ll-year-old black male [3].…”

Section: Discussionmentioning

confidence: 99%

CT localization of an aldosteronoma in a 10-year-old boy

et al. 1986

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Primary aldosteronism in children under 16 years of age is usually due to adrenal hyperplasia. We could find only seven cases in the literature where it was caused by a solitary adrenal adenoma; all but one were female. We describe the case of a 10-year-old Caucasian boy in whom a unilateral adrenal adenoma was demonstrated by high resolution computed tomography (CT) alone. The literature is reviewed.

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