Hypertension Caused by an Aldosterone-Secreting Adenoma

Bryer‐Ash, Michael; Wilson, Darrell M.; Tune, Bruce M.; Rosenfeld, Ron G.; Shochat, Stephen J.; Luetscher, John A.

doi:10.1001/archpedi.1984.02140450055017

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…:.. Osteoporose (in 3 Fällen besserte sie sich und blieb in drei weiteren Fällen unverändert wciterbestchen) und die Kopfschmerzen (2:2) zurück (Abb. [1][2][3][4][5][6]. Neben den drei Kindern (2 Mädchen und einem Jungen im Alter von 3, 4 und 6 Jahren) enthielt die Gruppe der Paticntcn mit AGS zwei Frauen im Alter von 28 und 29 Jahren.…”

Section: Ergebnisseunclassified

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Lokalisationsdiagnostische und postoperative Ergebnisse bei hormonproduzierenden Tumoren der Nebennierenrinde - Übersicht über 51 Fälle

Schier¹,

Hauss²,

Vetter³

et al. 1988

Eur J Pediatr Surg

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51 surgically treated cases with hormone-producing tumours of the adrenal cortex are evaluated for the reliability of preoperative localisation of diagnostic measures and postoperative results. 6 patients were children. The group contains 14 cases of Conn's syndrome, 32 cases of hypercortisolism, including 3 children, and 5 cases of AGS, 3 of which were children. The recommended work-up procedure is initiated by ultrasonography and followed by CT, possibly in combination with adrenal scintigraphy. This combination of a morphological and functional investigation established the correct diagnosis in all 51 cases. Laboratory values returned to normal levels in all cases, phenotypical aspects normalised in most cases. Deaths and complications occurred only in hypercortisolism and AGS.

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Section: Ergebnisseunclassified

“…Modeme Computertomographie-Geräte erreichen bei Nebennierentumoren von Erwachsenen eine Treffsicherheit von 97 % • Bei Kindern allerdings ist über den Nachweis z. B. kleiner Conn-Tumoren mit dem CT nur in Einzelfällen berichtet worden (2). 20-30 % der Aldosterome liegen unter einer Größe von 1 cm, in 63 % wiegen sie weniger als 6 Gramm.…”

Section: Diskussionunclassified

Lokalisationsdiagnostische und postoperative Ergebnisse bei hormonproduzierenden Tumoren der Nebennierenrinde - Übersicht über 51 Fälle

Schier¹,

Hauss²,

Vetter³

et al. 1988

Eur J Pediatr Surg

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“…Primary hyperaldosteronism is a syndrome classically characterized by hypertension, hypokalemia, elevated levels of serum aldosterone, and consistently suppressed levels of plasma renin activity [1,2]. Here we present the rare case of an adolescent, eventually diagnosed as Conn's syndrome, presenting with severe hypokalemia leading to ventricular tachycardia.…”

Section: Introductionmentioning

confidence: 97%

Functional Adrenal Adenoma Presenting as Ventricular Tachycardia in a Young Boy

Anuradha¹,

Makkar²,

Haldar³

et al. 2019

JCR

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Background: Ventricular tachycardia may be a solitary episode, complication of a structural heart disease or unusually, the manifestation of a serious electrolyte abnormality. Case Report: We present the rare case of a 13-year-old boy who presented with sudden onset ventricular tachycardia that was precipitated by severe hypokalemia. Subsequently, the associated hypertension and metabolic alkalosis prompted a search for an underlying endocrine abnormality. After investigations, the patient was diagnosed as a case of Conn's syndrome due to a functional adrenal adenoma-a rare diagnosis. Conclusion: The initial presentation of hyperaldosteronism in a child as ventricular tachycardia is extremely rare.

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“…primary aldosteronism ; childhood ; primary adrenal hyperplasia Primary aldosteronism characterized by hypertension, hypokalemia and hyporeninemia is very rare in childhood (Grim et al 1967 ;Ganguly et al 1980b ;New and Levine 1980;Bryer-Ash et al 1984;Oberfield et al 1984). Typically, three forms of primary aldosteronism are identified : Aldosterone-producing adenoma (APA), idiopathic hyperaldosteronism (IHA) and dexamethasone-…”

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confidence: 99%

Primary aldosteronism in childhood due to primary adrenal hyperplasia.

Kikuta

Sanjo

Nakajima

et al. 1988

Tohoku J. Exp. Med.

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We present an unusual case of primary aldosteronism in childhood.A 9-year-old boy had hypertension, hypokalemia, hyporeninemia and hyperaldosteronism.Dexamethasone administration decreased plasma aldosterone transiently but failed to correct the hyperaldosteronism, excluding dexamethasone-suppressible hyperaldosteronism. Plasma aldosterone decreased with upright posture and showed a circadian rhythm. Spironolactone treatment normalized blood pressure and serum potassium and lowered aldosterone secretion.During the studies, plasma aldosterone correlated with serum cortisol but not with plasma renin. Preoperative results indicated that this patient presented the functional features of aldosteronoma.Adrenal computed tomography, scintigraphy and left venography were not diagnostic of adrenal lesions. The left adrenal venous sampling showed hypersecretion of aldosterone from the left adrenal gland. The left adrenalectomy revealed micronodular hyperplasia but resulted in a prompt and sustained reversal of hypertension and hyperaldosteronism. These findings suggest that primary aldosteronism in this patient resulted from primary adrenal hyperplasia.Thus, adrenal hyperplasia is a heterogenous group of disorders and carefully selected studies allow prospective selection of appropriate treatment. primary aldosteronism ; childhood ; primary adrenal hyperplasia Primary aldosteronism characterized by hypertension, hypokalemia and hyporeninemia is very rare in childhood (Grim et al. 1967 ;Ganguly et al. 1980b ;New and Levine 1980;Bryer-Ash et al. 1984;Oberfield et al. 1984). Typically, three forms of primary aldosteronism are identified : Aldosterone-producing adenoma (APA), idiopathic hyperaldosteronism (IHA) and dexamethasone-

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Hypertension Caused by an Aldosterone-Secreting Adenoma

Cited by 10 publications

References 17 publications

Lokalisationsdiagnostische und postoperative Ergebnisse bei hormonproduzierenden Tumoren der Nebennierenrinde - Übersicht über 51 Fälle

Lokalisationsdiagnostische und postoperative Ergebnisse bei hormonproduzierenden Tumoren der Nebennierenrinde - Übersicht über 51 Fälle

Functional Adrenal Adenoma Presenting as Ventricular Tachycardia in a Young Boy

Primary aldosteronism in childhood due to primary adrenal hyperplasia.

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