Alert for non‐respiratory symptoms of coronavirus disease 2019 patients in epidemic period: A case report of familial cluster with three asymptomatic COVID‐19 patients

Abstract

prevention and management. Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. The discovery of the first asymptomatic carrier in this family cluster depends on the repeated and comprehensive epidemiological investigation by disease control experts. In addition, the combination of multiple detection methods can help clinicians find asymptomatic carriers as early as possible. In conclusion, the prevention and control experience of this family cluster showed that comprehensive rigorous epidemiological investigation and combination of multiple detection methods were of great value for the detection of hidden asymptomatic carriers.

Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain

“…As has occurred in other affected countries elsewhere, there is a risk of local clusters of transmission from imported cases [1,[43][44][45][46]. Precisely, the first case in Bolivia, originated the transmission to other seven cases in two different departments of the country, as the patient travelled to Santa Cruz, Cochabamba, La Paz and Oruro (Fig.…”

“…1). Close contact with active cases of COVID-19 represents a significant risk for SARS-CoV-2 transmission, even during the asymptomatic or presymptomatic stage, especially for relatives or friends [19,[46][47][48][49].…”

Asymptomatic cases with SARS‐CoV‐2 infection

“…Studies from single-center reported 4% to 6% cases with SARS-CoV-2 did not develop any symptom during the course of the disease. 5,6 Thus, there is very little probability that the virus-positive asymptomatic individuals will develop symptoms later, the ratio is slightly smaller than that of influenza, which was estimated at 56% to 80%. Recently, a preprint published on medRxiv analyzed the evolving epidemiology before and after nonpharmaceutical interventions put into effect using an SEIR model.…”

COVID-19: A Review on Molecular Basis, Pathogenic Mechanisms, Therapeutic Aspects and Future Projections<strong> </strong>

“…This is because we don't, as of now, have any reliable estimates of the total number of people infections by this virus. This is due the fact that many SARS-CoV-2 infected individuals are asymptomatic and never get tested Lu et al, 2020;Mizumoto et al, 2020;Lin et al, 2020). The number of people who are infected with SARS-CoV-2 may be notably higher than the actual confirmed cases indicating that the CFR of COVID-19 may be notably less than the estimated rate.…”