Aleukemic leukemia cutis

Ohno, Sayoko; Yokoo, Tadashi; Ohta, Miyuki; Yamamoto, Misaki; Danno, Kiichiro; Hamato, Noriyuki; K, Tomii; Ohno, Y; Kobashi, Yoichiro

doi:10.1016/0190-9622(90)70052-j

Cited by 68 publications

(36 citation statements)

References 9 publications

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“…In cases of infant leukemia cutis with or without widespread disease, spontaneous remission was observed in many cases [D'Orazio et al, 2008]. However, most cases without concomitant systemic leukemia developed leukemia in the bone marrow or relapsed at other extramedullary sites [Ohno et al, 1990;Byrd et al, 1995;Husak et al, 1999]. In our case, skin biopsy showed infiltration with blasts positive for MPO, CD68, and CD56, consistent with myeloid sarcoma.…”

Section: Discussionmentioning

confidence: 62%

Complex Three-Way Translocation Involving MLL, ELL, RREB1, and CMAHP Genes in an Infant with Acute Myeloid Leukemia and t(6;19;11)(p22.2;p13.1;q23.3)

Tuborgh

Meyer

Marschalek

et al. 2013

Cytogenet Genome Res

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Rearrangements affecting the MLL gene in hematological malignancies are associated with poor prognosis. Most often they are reciprocal translocations and more rarely complex forms involving at least 3 chromosomes. We describe an unusual case with cutaneous leukemic infiltrates that waxed and waned until progression to acute myeloid leukemia, AML-M5. The leukemic cells harbored a novel apparent 3-way translocation t(6;19;11)(p22.2;p13.1;q23.3). We utilized advanced molecular cytogenetic methods including 24-color karyotyping, high-resolution array comparative genomic hybridization (aCGH) and DNA sequencing to characterize the genomic complement in the leukemic cells from aspirated bone marrow cells at AML diagnosis. Karyotyping showed 47,XY,t(6;19;11)(p22;p13;q23),+der(6)t(6;11)(p22;q23)[17]/48,sl,+8[3]/48,sl,+8,der(12)t(1;12)(q11;p13)[3]/ 48,sdl,der(Y)t(Y;1)(q12;q11),+8[7] conferring MLL-ELL fusion. Oligo-aCGH analysis confirmed gains of 6p22qter and 11q23.3qter involving the CMAHP and MLL genes, respectively. DNA sequencing disclosed an additional breakpoint at 6p24.3 (at RREB1 gene). Retrospective fluorescence in situ hybridization revealed presence of the MLL-involving rearrangement in the initial stages of disease before clear morphological signs of bone marrow involvement. The patient responded well to therapy and remains in remission >6 years from diagnosis. This apparent 3-way translocation is remarkable because of its rarity and presentation with myeloid sarcoma, and may, as more cases are characterized, further our understanding onto how such complex translocations contribute to promote leukemogenesis and respond to therapy.

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Section: Discussionmentioning

confidence: 62%

Complex Three-Way Translocation Involving MLL, ELL, RREB1, and CMAHP Genes in an Infant with Acute Myeloid Leukemia and t(6;19;11)(p22.2;p13.1;q23.3)

Tuborgh

Meyer

Marschalek

et al. 2013

Cytogenet Genome Res

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“…LC is rare without frank leukemia ("aleukemic" LC). Monocytic derivation of aleukemic LC was documented in approximately 20% of the reported cases [2] and was always followed by systemic leukemia of the same cell origin [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…LC-M without systemic leukemia is rare and has been termed "aleukemic" skin infiltration [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: A case report

Yavorkovsky

Zain

et al. 2001

Am. J. Hematol.

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A case of leukemia cutis (LC) of monocytic lineage in a patient with myelodysplastic syndrome (MDS) is presented. Cutaneous infiltrates were recognized concurrent with diagnosis of refractory anemia (RA) with monocytosis. Skin infiltrates subsequently spontaneously regressed although MDS progressed with increasing monocytosis, anemia, and thrombocytopenia. Death occurred 6 months after diagnosis with evolution of acute monoblastic leukemia complicated by sepsis. This case supports previous observations of poor prognosis associated with leukemia cutis. LC associated with MDS is reviewed including the role of monocytes.

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“…One was a 10-year-old girl with type 1 diabetes mellitus and celiac disease (neither of which is typically associated with PNGD) who had an annular plaque and papules in a linear array focally on the ankles. 1 The other was a 12-year-old girl with systemic lupus erythematosus who developed annular plaques in the girdle regions 2 ; the morphology and distribution in this patient were typical of interstitial granulomatous dermatitis, which some (but not all) authors believe exists on a spectrum with PNGD. In contrast, our patient had classic PNGD ( papulonodules on extensor surfaces), which to our knowledge has not been previously described in a child.…”

Section: Isolated Cutaneous Extramedullary Relapse Of Leukemia Confirmentioning

confidence: 97%

“…Because of its rarity, particularly in the posttransplantation setting, the optimal treatment strategy has not been established. [1][2][3][4][5] Options include an immunologic approach to maximize potential graft-versus-tumor effect through withdrawal of immunosuppression and/or donor leukocyte infusion, radiation therapy, chemotherapy, and total body electron therapy.…”

Section: Isolated Cutaneous Extramedullary Relapse Of Leukemia Confirmentioning

confidence: 99%

Isolated cutaneous extramedullary relapse of leukemia confirmed by fluorescent in situ hybridization analysis

Friedman

Jambusaria

Shinohara

et al. 2012

Journal of the American Academy of Dermatology

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Aleukemic leukemia cutis

Cited by 68 publications

References 9 publications

Complex Three-Way Translocation Involving <b><i>MLL</i></b>, <b><i>ELL</i></b>, <b><i>RREB1</i></b>, and <b><i>CMAHP </i></b>Genes in an Infant with Acute Myeloid Leukemia and t(6;19;11)(p22.2;p13.1;q23.3)

Complex Three-Way Translocation Involving <b><i>MLL</i></b>, <b><i>ELL</i></b>, <b><i>RREB1</i></b>, and <b><i>CMAHP </i></b>Genes in an Infant with Acute Myeloid Leukemia and t(6;19;11)(p22.2;p13.1;q23.3)

Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: A case report

Isolated cutaneous extramedullary relapse of leukemia confirmed by fluorescent in situ hybridization analysis

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