1980
DOI: 10.1016/s0065-2776(08)60046-2
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Aleutian Disease of Mink

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Cited by 108 publications
(85 citation statements)
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References 55 publications
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“…The disease is characterized by hyperstimulation of the humoral immune system, which causes plasmacytosis and hypergammaglobulinemia, occasionally with extreme serum gamma globulin values higher than 100 mg/ml (44). Such a condition normally contains a monoclonal immunoglobulin component, and this component has antibody activity toward the ADV VP1/ VP2 capsid (7).…”
Section: Discussionmentioning
confidence: 99%
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“…The disease is characterized by hyperstimulation of the humoral immune system, which causes plasmacytosis and hypergammaglobulinemia, occasionally with extreme serum gamma globulin values higher than 100 mg/ml (44). Such a condition normally contains a monoclonal immunoglobulin component, and this component has antibody activity toward the ADV VP1/ VP2 capsid (7).…”
Section: Discussionmentioning
confidence: 99%
“…In spite of these active immune functions, the virus persists, and the reason for this is not fully understood, although there are theories (55). Persistent virus and antibody cause immune complex formation, and AD is known as a classical example of immune complex disease (type 3 hypersensitivity) characterized by immune complex formation, glomerulonephritis, and arteritis (44).…”
Section: Discussionmentioning
confidence: 99%
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“…More recently, clear differences in'strain susceptibility have been observed in both induced and spontaneously occurring forms of systemic vasculitis in animals (reviewed in 11). In both Aleutian disease of mink and chronic lymphocytic choriomeningitis in mice, vasculitis is thought to be a manifestation of the host immune response to a virus rather than a cytopathic effect of the virus per se (12,13).…”
Section: Discussionmentioning
confidence: 99%
“…This is one of many examples of the inability of the Ig response to deal with a persistent, intracellular virus. Another classical case is Aleutian disease of mink (67), where tissues are heavily infiltrated with plasma cells and there are massive levels of virus-specific Ig in serum. Viruses such as measles and HIV, which form syncitia (68) and may transmit from cell to cell without ever being free in tissue fluid, are particularly dangerous in this regard.…”
Section: Viral Persistence and Immunitymentioning
confidence: 99%