In the representation theory of real reductive Lie groups, many objects have finiteness properties. For example, the lengths of Verma modules and principal series representations are finite, and more precisely, they are bounded. In this paper, we introduce a notion of uniformly bounded families of holonomic D-modules to explain and find such boundedness properties.A uniform bounded family has good properties. For instance, the lengths of modules in the family are bounded and the uniform boundedness is preserved by direct images and inverse images. By the Beilinson-Bernstein correspondence, we deduce several boundedness results about the representation theory of complex reductive Lie algebras from corresponding results of uniformly bounded families of D-modules. In this paper, we concentrate on proving fundamental properties of uniformly bounded families, and preparing abstract results for applications to the branching problem and harmonic analysis.